ALDH1B1: A Mitochondrial Enzyme in Cellular Respiration and Alcohol Metabolism

Target Name: ALDH1B1

NCBI ID: G219

ALDH1B1: A Mitochondrial Enzyme in Cellular Respiration and Alcohol Metabolism

ALDH1B1 (Mitochondrial aldehyde dehydrogenase X) is a gene that encodes a protein known as mitochondrial aldehyde dehydrogenase X. This protein plays a crucial role in the metabolism of cells in the body, particularly in the process of cellular respiration.

Mitochondrial aldehyde dehydrogenase X is a member of the superfamily of NAD+-dependent enzymes, which are involved in the transfer of electrons in the electron chain of the mitochondrial ATP synthase. This protein is localized to the mitochondria, where it is a key component of the electron transport chain, which is responsible for generating the energy needed for cellular respiration.

The function of ALDH1B1 (Mitochondrial aldehyde dehydrogenase X) is to catalyze the reaction between carbon dioxide and water to produce carbon dioxide and oxygen. This reaction occurs during the second step of cellular respiration, known as the Krebs cycle or TCA cycle. The production of carbon dioxide and oxygen allows for the formation of ATP, which is the energy currency of the cell.

ALDH1B1 (Mitochondrial aldehyde dehydrogenase X) is a protein that is expressed in most tissues of the body, including muscle, heart, brain, and red blood cells. It is also highly expressed in the liver, where it is involved in the metabolism of a variety of compounds, including alcohol and drugs.

One of the unique features of ALDH1B1 (Mitochondrial aldehyde dehydrogenase X) is its expression pattern in the brain. This protein is highly expressed in the brain, and is also the target of a drug called ALDH101635, which is currently being studied as a potential therapeutic agent for the treatment of various neurological disorders, including Alzheimer's disease.

Another potential drug target for ALDH1B1 (Mitochondrial aldehyde dehydrogenase X) is its role in the metabolism of alcohol. Alcohol consumption can lead to the accumulation of toxic metabolites in the liver, which can damage the mitochondria and contribute to the development of various neurological disorders, including Alzheimer's disease.

In addition to its potential drug targets, ALDH1B1 (Mitochondrial aldehyde dehydrogenase X) is also of interest as a biomarker for certain diseases. For example, individuals with certain genetic mutations, such as those with the disease progressive familial intrahepatic cholestasis (PFIC), have been shown to have reduced levels of ALDH1B1 (Mitochondrial aldehyde dehydrogenase X).

Overall, ALDH1B1 (Mitochondrial aldehyde dehydrogenase X) is a protein that plays a crucial role in the metabolism of cells in the body. Its function is to catalyze the reaction between carbon dioxide and water to produce carbon dioxide and oxygen during the second step of cellular respiration. This protein is also expressed in most tissues of the body and is a potential drug target for the treatment of various neurological disorders. Its role in the metabolism of alcohol and its potential as a biomarker for certain diseases also make it an attractive target for further research.

Protein Name: Aldehyde Dehydrogenase 1 Family Member B1

Functions: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

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