ALDH1A3: A Potential Drug Target Or Biomarker (G220)

Target Name: ALDH1A3

NCBI ID: G220

ALDH1A3: A Potential Drug Target Or Biomarker

ALDH1A3 (AL1A3_HUMAN), a member of the ATP-binding Cassette (ABC) family, is a protein that plays a crucial role in the regulation of ion channels and the transport of various molecules across cell membranes. The study of ALDH1A3 and its potential as a drug target or biomarker has become increasingly interested in recent years due to its involvement in a wide range of physiological processes, including the regulation of pain perception, inflammation, and cellular signaling.

ALDH1A3 is a 21-kDa protein that is expressed in most tissues of the body. It is a member of the ATP-binding Cassette (ABC) family, which is a large transmembrane protein family that plays a fundamental role in the regulation of ion channels and the transport of various molecules across cell membranes. The ABC family consists of eight subfamilies, including ALDH1A3, which is characterized by the presence of a 16 amino acid loop at its C-terminus.

ALDH1A3 is involved in the regulation of a wide range of physiological processes, including the regulation of pain perception, inflammation, and cellular signaling. For example, ALDH1A3 has been shown to play a role in the regulation of pain perception. ALDH1A3 is expressed in the highest amount in the pain-sensitive neurons, such as in the dorsal root of the spinal cord, and it is involved in the regulation of the release of pain-related neurotransmitters. Additionally, ALDH1A3 has been shown to play a role in the regulation of inflammation. It is expressed in the inflammatory cells, such as neutrophils, and is involved in the regulation of the production of pro-inflammatory cytokines.

ALDH1A3 is also involved in the regulation of cellular signaling, including the regulation of cell division and the regulation of cell signaling pathways. For example, ALDH1A3 has been shown to play a role in the regulation of cell division. It is expressed in the S phase of the cell cycle and is involved in the regulation of the loading of DNA into the mitotic spindle. Additionally, ALDH1A3 has been shown to play a role in the regulation of cell signaling pathways. It is involved in the regulation of the production of various signaling molecules, including neurotransmitters and cytokines.

Given its involvement in a wide range of physiological processes, ALDH1A3 has potential as a drug target or biomarker. Many studies have investigated the effects of drugs on ALDH1A3 expression and function, with some results indicating that ALDH1A3 may be a promising drug target for various diseases. For example, some studies have shown that inhibition of ALDH1A3 can reduce pain perception and inflammation in animal models of pain and inflammation. Additionally, some studies have shown that ALDH1A3 is involved in the regulation of cell division and that inhibition of ALDH1A3 may have implications for the regulation of cancer cell division.

In conclusion, ALDH1A3 is a protein that is involved in the regulation of a wide range of physiological processes, including pain perception, inflammation, and cellular signaling. Its potential as a drug target or biomarker has generated a great deal of interest in recent years due to its involvement in these processes. Further research is needed to fully understand the role of ALDH1A3 in these processes and to explore its potential as a drug.

Protein Name: Aldehyde Dehydrogenase 1 Family Member A3

Functions: NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:27759097). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (PubMed:27759097). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity)

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