AHRR: A Protein Critical for Gene Expression and Disease Development

Target Name: AHRR

NCBI ID: G57491

AHRR: A Protein Critical for Gene Expression and Disease Development

The AHRR (aryl hydrocarbon receptor repressor) is a protein that is expressed in various tissues throughout the body, including the brain, lungs, heart, kidneys, and intestines. It is a member of the superfamily of G-coupled proteins, which are characterized by the presence of a hydrogen bonding acceptor and a zinc finger transcription factor.

The primary function of the AHRR is to regulate the expression of genes in response to environmental stimuli, such as aryl hydrocarbons (AHs), which are naturally occurring compounds that can be found in various tissues and can have both beneficial and adverse effects on human health.

AHRR is a critical regulator of gene expression, and it has been implicated in a wide range of physiological processes that are important for human health and development. One of the most significant functions of AHRR is its role in protecting the body against harmful effects of AHs.

Research has shown that AHRR plays a crucial role in modulating the expression of genes involved in the detoxification and metabolism of AHs, which are known to be potent toxins that can cause a wide range of health problems, including cancer, neurodegenerative diseases, and reproductive disorders.

In addition to its role in protecting against AHs, AHRR has also been shown to play a key role in the regulation of various physiological processes that are important for human health and development. For example, AHRR has been shown to be involved in the regulation of cell growth, differentiation, and survival, as well as in the regulation of inflammation and immune responses.

AHRR has also been shown to play a key role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and cardiovascular disease. For example, studies have shown that AHRR is often expressed in tissues that are affected by these conditions, and that it is involved in the regulation of the expression of genes involved in the development and progression of these diseases.

Despite its importance for a wide range of physiological processes, the study of AHRR is still in its infancy, and much more research is needed to fully understand its role in the regulation of gene expression and the development and progression of various diseases.

In conclusion, the AHRR is a protein that is critical for the regulation of gene expression and the development and progression of various diseases. Further research is needed to fully understand its role in these processes and to develop effective treatments for AHRR-related diseases.

Protein Name: Aryl Hydrocarbon Receptor Repressor

Functions: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site

More Common Targets