AIMP1: A promising drug target for small inducible cytokine subfamily E member 1

Target Name: AIMP1

NCBI ID: G9255

AIMP1: A promising drug target for small inducible cytokine subfamily E member 1

Abstract:

Small inducible cytokine subfamily E member 1 (AIMP1) is a protein that plays a crucial role in the regulation of cellular processes essential for human health and disease. It has been identified as a potential drug target due to its unique mechanism of action and its involvement in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. In this article, we will discuss the discovery, structure, and potential therapeutic applications of AIMP1 as a drug target.

Introduction:

AIMP1, also known as miR-201, is a non-coding RNA molecule that is expressed in various tissues and cells throughout the body. It is a member of the small inducible cytokine subfamily E, which includes a diverse range of cytokines that play a crucial role in the regulation of cellular processes, including cell growth, differentiation, and inflammation.

Recent studies have identified AIMP1 as a potential drug target due to its unique mechanism of action and its involvement in various diseases. One of the key factors that make AIMP1 an attractive drug target is its ability to regulate the expression of target genes. AIMP1 has been shown to regulate the expression of genes involved in cell growth, differentiation, and apoptosis, which can lead to the inhibition of cancer cell proliferation and the stimulation of anti-inflammatory responses.

Structure and function:

The structure of AIMP1 is unique due to its ability to self-dimerize and to interact with other proteins. AIMP1 is a 14-kDa protein that contains a single exon and a single intron. It has a unique N-terminus that consists of a 23 amino acid residue and a GFP-tag. The C-terminus of AIMP1 consists of a 31 amino acid residue, which is involved in the formation of a GFP-containing construct that can be used for cell culture studies.

AIMP1 has been shown to play a role in the regulation of cellular processes essential for human health and disease. One of the key functions of AIMP1 is its ability to regulate the expression of genes involved in cell growth, differentiation, and apoptosis. AIMP1 has been shown to inhibit the expression of genes involved in cell cycle progression and apoptosis, which can lead to the inhibition of cancer cell proliferation.

In addition to its role in cell growth and apoptosis, AIMP1 has also been shown to regulate the production of pro-inflammatory cytokines. AIMP1 has been shown to inhibit the production of pro-inflammatory cytokines, such as TNF-伪, IL-1尾, and IL-6, which are involved in the regulation of inflammation.

Potential therapeutic applications:

AIMP1 has the potential to be a drug target for various diseases due to its unique mechanism of action and its involvement in various processes that are associated with human disease. One of the key potential therapeutic applications of AIMP1 is its potential as a cancer therapeutic. AIMP1 has been shown to inhibit the expression of genes involved in cell cycle progression and apoptosis, which can lead to the inhibition of cancer cell proliferation. Therefore, AIMP1 may be an effective agent for the treatment of various cancers, including breast, ovarian, and prostate cancers.

In addition to its potential as a cancer therapeutic, AIMP1 has also been shown to have potential therapeutic applications in neurodegenerative disorders. AIMP1 has been shown to regulate the production of pro-inflammatory cytokines, which are involved in the regulation of inflammation

Protein Name: Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 1

Functions: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550)

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