IGFBP2: The Potential Drug Target and Biomarker (G3485)

Target Name: IGFBP2

NCBI ID: G3485

IGFBP2: The Potential Drug Target and Biomarker

Introduction

The insulin-like growth factor 2 (IGFBP2) is a protein that plays a crucial role in the regulation of bone and muscle growth and development. It is a member of the IGFBP family, which also includes IGFBP1 and IGFBP3, and is expressed in various tissues throughout the body, including bone marrow, fat tissue, and the brain. IGFBP2 has been shown to be involved in the development and maintenance of bone mass, and is also involved in the regulation of muscle mass and function.

The IGFBP2 gene has been identified as a potential drug target in the field of osteoarthritis and bone tumor treatment. IGFBP2 gene knockout or inhibition can significantly reduce the number of osteoclasts and osteoblasts in mice, thereby inhibiting the development of osteoarthritis. IGFBP2 gene knockout or inhibition can also significantly reduce the growth rate of bone tumor cells in mice.

IBP-2: A Potential Drug Target

IGFBP2 is a signal transduction molecule involved in regulating a variety of biological processes, including cell proliferation, differentiation, migration and apoptosis. IGFBP2 plays a key role in bone and muscle development by regulating the number of osteoclasts and osteoblasts to maintain bone and muscle development. IGFBP2 is also involved in regulating fat metabolism, including the growth of adipocytes and the regulation of fat metabolism.

Research shows that IGFBP2 plays an important role in the development of osteoarthritis and bone tumors. IGFBP2 gene knockout or inhibition can significantly reduce the number of osteoclasts and osteoblasts in mice, thereby inhibiting the development of osteoarthritis. IGFBP2 gene knockout or inhibition can also significantly reduce the growth rate of bone tumor cells in mice.

IBP-2: A Potential Biomarker

IGFBP2 is a protein that serves as a biomarker for detecting the development of osteoarthritis and bone tumors. IGFBP2 gene knockout or inhibition can significantly reduce the number of osteoclasts and osteoblasts in mice, thereby inhibiting the development of osteoarthritis. IGFBP2 gene knockout or inhibition can also significantly reduce the growth rate of bone tumor cells in mice.

Protein Name: Insulin Like Growth Factor Binding Protein 2

Functions: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors

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