KLPL2: A Potential Drug Target for Various Diseases (G3652)

Target Name: IPP

NCBI ID: G3652

KLPL2: A Potential Drug Target for Various Diseases

Kelch-like protein 27 (KLPL2) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and lungs. It is a member of the Kelch family of proteins, which are characterized by the presence of a catalytic domain and a variable region that contains conserved conserved amino acid sequences. KLPL2 is unique among Kelch-like proteins in that it is a transmembrane protein, meaning that it spans the cell membrane and is involved in various cellular processes.

Disease and Research

KLPL2 has been extensively studied due to its involvement in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the main research areas of focus for KLPL2 is its potential as a drug target. KLPL2 has been shown to play a role in various cellular processes, including cell signaling, cell adhesion, and neurotransmission. Several studies have suggested that KLPL2 may be a promising drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In cancer, KLPL2 has been shown to be involved in the development and progression of various types of cancer, including breast cancer, lung cancer, and colon cancer. For example, a study by the National Cancer Institute found that high levels of KLPL2 were associated with poor prognosis in patients with pancreatic cancer. Another study by the University of California, San Diego found that KLPL2 was overexpressed in the brains of patients with Alzheimer's disease, a neurodegenerative disorder.

In neurodegenerative diseases, KLPL2 has been shown to be involved in the development and progression of various disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. For example, a study by the National Institute on Aging found that KLPL2 was overexpressed in the brains of patients with Alzheimer's disease.

In autoimmune disorders, KLPL2 has been shown to be involved in the development and progression of various disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. For example, a study by the University of California, San Diego found that KLPL2 was overexpressed in the blood of patients with rheumatoid arthritis.

Conclusion

KLPL2 is a protein that has been extensively studied due to its involvement in various diseases. Its unique transmembrane structure and conserved conserved amino acid sequences make it a promising candidate for drug targeting. Further research is needed to fully understand the role of KLPL2 in various diseases. and to develop effective treatments.

Protein Name: Intracisternal A Particle-promoted Polypeptide

Functions: May play a role in organizing the actin cytoskeleton

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