LINC00937: A Long Intergenic Non-Protein-Coding RNA as a Drug Target or Biomarker

Target Name: LINC00937

NCBI ID: G389634

Other Name(s): long intergenic non-protein coding RNA 937 | Long intergenic non-protein coding RNA 937

LINC00937: A Long Intergenic Non-Protein-Coding RNA as a Drug Target or Biomarker

LINC00937 is a long non-coding RNA (lncRNA) that has been identified in various studies as a potential drug target or biomarker. It is a transcribed RNA molecule that is longer than 200 nucleotides and can be located in different genomic regions, including introns and exons of gene transcripts. LINC00937 has been shown to play a role in various cellular processes, including cell adhesion, migration, and survival.

Drug Target Potential

LINC00937 has been identified as a potential drug target due to its unique structure and function. It is a protein-like molecule that has a predicted transmembrane domain and a clear cytoplasmic domain. Additionally, it has been shown to interact with various protein partners, including the protein encoded by the gene PDGF-尾. This interaction suggests that LINC00937 could be a useful target for small molecule inhibitors that target PDGF-尾 signaling pathways.

Biomarker Potential

LINC00937 has also been identified as a potential biomarker for various diseases, including cancer. Its expression has been shown to be elevated in various cancer types, including breast, ovarian, and colorectal cancers. Additionally, it has been shown to be associated with cancer stem cell properties, which may make it a useful biomarker for cancer therapy.

Analysis of LINC00937

To further understand the function of LINC00937, researchers have used various bioinformatics tools to analyze its sequence and structure. They have shown that LINC00937 has a unique five-exon cDNA that spans the length of 1,981 base pairs. The cDNA has a predicted translation efficiency of 0.49, which suggests that it is a functional RNA molecule.

In addition, researchers have used RNA sequencing (RNA-seq) to identify the differentially expressed genes (DEGs) that are associated with LINC00937 expression. They have shown that LINC00937 is highly expressed in various tissues and cells, including the brain, pancreas, and heart. Additionally, they have identified a variety of gene expression patterns that are associated with LINC00937 expression, including the expression of genes involved in cell adhesion, migration, and survival.

Conclusion

In conclusion, LINC00937 is a long non-coding RNA that has been identified as a potential drug target and biomarker. Its unique structure and function, as well as its association with various cellular processes, make it a promising candidate for further study. Further research is needed to fully understand the role of LINC00937 in various biological processes and to determine its potential as a drug or biomarker.

Protein Name: Long Intergenic Non-protein Coding RNA 937

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