Olfactory Receptor 52E8: Potential Drug Target and Model Protein

Olfactory Receptor 52E8: Potential Drug Target and Model Protein

Olfactory receptor, family 52, subfamily E, member 8 (OR52E8) is a protein that plays a crucial role in the sense of smell. It is a transmembrane protein that is expressed in the peripheral nervous system, including the olfactory nerve. OR52E8 is a member of the Olfactory Receptor gene family, which is a large gene family that encodes the proteins that detect and respond to odors.

OR52E8 is a pseudogene, which means that it is a genetic copy of a gene that does not code for a functional protein. OR52E8 is expressed in the olfactory system, but its function is not well understood. Some studies have suggested that OR52E8 may be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Despite its potential involvement in neurodegenerative diseases, OR52E8 is also a potential drug target. One approach to targeting OR52E8 is to use small molecules that can modulate its activity. For example, a team of researchers at the University of California, San Diego has developed a compound called CK-101, which is a peptide that binds to OR52E8 and inhibits its activity.

Another approach to targeting OR52E8 is to use antibodies that can detect and label it. This can be done using techniques such as immunofluorescence, which allows researchers to visualize the protein in the olfactory system and determine its levels. One researcher has used antibodies against OR52E8 to label the protein in the olfactory system and study its localization to different cell types.

While more research is needed to fully understand the role of OR52E8 in the olfactory system and its potential as a drug target, it is clear that OR52E8 is an important protein that is involved in the sense of smell. Further research is needed to determine its full function and to explore its potential as a drug target.

Protein Name: Olfactory Receptor Family 52 Subfamily E Member 8

Functions: Odorant receptor

More Common Targets

OR52H1 | OR52I1 | OR52I2 | OR52J3 | OR52K1 | OR52K2 | OR52K3P | OR52L1 | OR52M1 | OR52N1 | OR52N4 | OR52N5 | OR52R1 | OR52W1 | OR52Z1P | OR56A1 | OR56A3 | OR56A4 | OR56A5 | OR56B1 | OR56B4 | OR5A1 | OR5A2 | OR5AC1 | OR5AC2 | OR5AK2 | OR5AK4P | OR5AN1 | OR5AP2 | OR5AR1 | OR5AS1 | OR5AU1 | OR5B12 | OR5B17 | OR5B2 | OR5B21 | OR5B3 | OR5BA1P | OR5C1 | OR5D13 | OR5D14 | OR5D16 | OR5D17P | OR5D18 | OR5E1P | OR5F1 | OR5H1 | OR5H14 | OR5H15 | OR5H2 | OR5H4P | OR5H6 | OR5I1 | OR5K1 | OR5K2 | OR5K3 | OR5K4 | OR5L1 | OR5L2 | OR5M1 | OR5M10 | OR5M11 | OR5M3 | OR5M4P | OR5M8 | OR5M9 | OR5P1P | OR5P2 | OR5P3 | OR5T1 | OR5T2 | OR5T3 | OR5V1 | OR5W2 | OR6A2 | OR6B1 | OR6B2 | OR6B3 | OR6C1 | OR6C2 | OR6C3 | OR6C4 | OR6C65 | OR6C70 | OR6C74 | OR6C75 | OR6C76 | OR6F1 | OR6J1 | OR6K2 | OR6K3 | OR6M1 | OR6N1 | OR6N2 | OR6P1 | OR6Q1 | OR6R2P | OR6S1 | OR6T1 | OR6W1P