OR5 Gene Family: Role in Human Sensory Function (G79295)

OR5 Gene Family: Role in Human Sensory Function

Olfactory receptor family 5 (OR5) is a subfamily of G protein-coupled receptors (GPCRs) that play a crucial role in human sensory function, particularly smell and taste. OR5 is composed of four different genes: OR5A, OR5B, OR5C, and OR5D. While all four genes encode for GPCRs that are expressed in the peripheral nervous system (PNS), OR5B and OR5C are predominantly expressed in the brain, while OR5A and OR5D are expressed in the skin, hair, and nail.

OR5 is a family of GPCRs that are known for their role in mediating sensory input and the resulting neural responses. The first OR5 gene was identified in 1995 and has since been shown to play a role in the sense of smell. OR5A is the most well-studied gene in the OR5 family, and it is expressed in the olfactory cortex, which is the part of the brain responsible for processing sensory information.

OR5A is a 15-kDa transmembrane protein that is composed of an extracellular loop, a transmembrane segment, and an intracellular terminal. The extracellular loop is the region of the protein that interacts with the cell surface, while the transmembrane segment is responsible for the protein's ability to span the cell membrane. The intracellular terminal is the region of the protein that interacts with other proteins inside the cell.

OR5A has been shown to play a role in mediating the sense of smell by transmitting sensory information from the olfactory neurons to the brain. OR5A has been shown to interact with several different proteins, including the neurotransmitter acetylcholine, which is involved in the sensation of taste and texture. In addition, OR5A has been shown to interact with the G protein-coupled receptor GPR85, which is involved in the sense of touch.

While OR5A is the most well-studied gene in the OR5 family, additional studies have identified several other genes that are involved in the OR5 system. One of the most promising new genes is OR5B, which is also expressed in the olfactory cortex. OR5B is a 24-kDa transmembrane protein that is similar to OR5A in terms of its structure and function.

OR5B has been shown to play a role in the development and maintenance of the olfactory system. For example, studies have shown that OR5B is involved in the formation of new neurons in the olfactory system, and that it plays a role in the regulation of cell death in the olfactory system. In addition, OR5B has been shown to interact with the protein TRPV2, which is involved in the sense of touch.

Another gene that is involved in the OR5 system is OR5C, which is also expressed in the olfactory cortex. OR5C is a 12-kDa transmembrane protein that is similar to OR5A and OR5B in terms of its structure and function.

OR5C has been shown to play a role in the regulation of sensory input in the olfactory system. For example, studies have shown that OR5C is involved in the sensitivity of the olfactory system to different stimuli, such as the smell of linalool or the taste of acetic acid. In addition, OR5C has been shown to interact with the protein GPR75, which is involved in the sense of taste.

The fourth gene in the OR5 family is OR5D, which is also expressed in the olfactory cortex. OR5D is a 21-kDa transmembrane protein that is similar to OR5A and OR

Protein Name: Olfactory Receptor Family 5 Subfamily H Member 6

Functions: Odorant receptor

More Common Targets

OR5I1 | OR5K1 | OR5K2 | OR5K3 | OR5K4 | OR5L1 | OR5L2 | OR5M1 | OR5M10 | OR5M11 | OR5M3 | OR5M4P | OR5M8 | OR5M9 | OR5P1P | OR5P2 | OR5P3 | OR5T1 | OR5T2 | OR5T3 | OR5V1 | OR5W2 | OR6A2 | OR6B1 | OR6B2 | OR6B3 | OR6C1 | OR6C2 | OR6C3 | OR6C4 | OR6C65 | OR6C70 | OR6C74 | OR6C75 | OR6C76 | OR6F1 | OR6J1 | OR6K2 | OR6K3 | OR6M1 | OR6N1 | OR6N2 | OR6P1 | OR6Q1 | OR6R2P | OR6S1 | OR6T1 | OR6W1P | OR6X1 | OR6Y1 | OR7A10 | OR7A17 | OR7A5 | OR7C1 | OR7C2 | OR7D1P | OR7D2 | OR7D4 | OR7E104P | OR7E109P | OR7E121P | OR7E122P | OR7E125P | OR7E13P | OR7E140P | OR7E14P | OR7E155P | OR7E156P | OR7E19P | OR7E22P | OR7E24 | OR7E25P | OR7E29P | OR7E37P | OR7E41P | OR7E47P | OR7E5P | OR7E62P | OR7E84P | OR7E85BP | OR7E87P | OR7E91P | OR7E94P | OR7G1 | OR7G2 | OR7G3 | OR7M1P | OR8A1 | OR8B12 | OR8B2 | OR8B3 | OR8B4 | OR8B6P | OR8B7P | OR8B8 | OR8D1 | OR8D2 | OR8D4 | OR8F1P | OR8G1