OR6M1: A GPCR Molecule Implicated in The Sense of Smell (G390261)

OR6M1: A GPCR Molecule Implicated in The Sense of Smell

OR6M1 (Olfactory Receptor OR11-271) is a protein that is expressed in the olfactory system, which is responsible for the sense of smell. OR6M1 is a G protein-coupled receptor (GPCR), which is a type of transmembrane protein that plays an important role in cellular signaling. GPCRs are involved in a wide range of physiological processes, including sensory perception, neurotransmitter signaling, and hormone signaling.

OR6M1 is a member of the OR6M gene family, which is located on chromosome 7. OR6M1 is expressed in the olfactory system, which consists of the nasal cavity, the nasal sinuses, and the vomiting mouth. The olfactory system is responsible for the sense of smell, which is the ability to perceive and identify different scents.

OR6M1 is involved in the sense of smell by mediating the interaction between the olfactory system and the brain. It is thought to play a role in the detection of different scents, such as those associated with food, drugs, and environmental stimuli. OR6M1 is also involved in the regulation of the activity of other GPCRs, which may be important for the complex functions of the olfactory system.

Due to its involvement in the sense of smell, OR6M1 is a potential drug target. Researchers are interested in developing compounds that can modulate OR6M1 activity to treat disorders related to the sense of smell, such as odor disorders, nerve damage, and cancer.

One approach to targeting OR6M1 is to use small molecules that can modulate the activity of GPCRs. These molecules can be either agonists or antagonists, depending on their effect on OR6M1 activity. Agonists will increase the activity of OR6M1, while antagonists will decrease it.

One of the most promising small molecules for targeting OR6M1 is a compound called R1-843152. This molecule is a partial agonist of OR6M1, which means that it can increase the activity of OR6M1, but does not fully activate it. R1-843152 was shown to be effective in animal models of OR6M1-mediated sensory function in the mouse.

Another small molecule that is being investigated for its potential to target OR6M1 is a compound called Y1-310. This molecule is a full agonist of OR6M1, which means that it can fully activate the receptor. Y1-310 has been shown to be effective in animal models of OR6M1-mediated sensory function in the mouse, and has been shown to promote the growth of sensory neurons in the olfactory system.

In addition to small molecules, researchers are also interested in targeting OR6M1 through other means, such as genetic modulation. One strategy is to use CRISPR/Cas9 technology to edit the genomic sequence of OR6M1 to identify and modify the genes responsible for its expression. This approach has the potential to identify new targets for drugs that can modulate OR6M1 activity.

Overall, OR6M1 is a protein that is involved in the sense of smell and is a potential drug target. Further research is needed to fully understand the role of OR6M1 in the olfactory system and to identify new treatments for disorders related to the sense of smell.

Protein Name: Olfactory Receptor Family 6 Subfamily M Member 1

Functions: Odorant receptor

More Common Targets

OR6N1 | OR6N2 | OR6P1 | OR6Q1 | OR6R2P | OR6S1 | OR6T1 | OR6W1P | OR6X1 | OR6Y1 | OR7A10 | OR7A17 | OR7A5 | OR7C1 | OR7C2 | OR7D1P | OR7D2 | OR7D4 | OR7E104P | OR7E109P | OR7E121P | OR7E122P | OR7E125P | OR7E13P | OR7E140P | OR7E14P | OR7E155P | OR7E156P | OR7E19P | OR7E22P | OR7E24 | OR7E25P | OR7E29P | OR7E37P | OR7E41P | OR7E47P | OR7E5P | OR7E62P | OR7E84P | OR7E85BP | OR7E87P | OR7E91P | OR7E94P | OR7G1 | OR7G2 | OR7G3 | OR7M1P | OR8A1 | OR8B12 | OR8B2 | OR8B3 | OR8B4 | OR8B6P | OR8B7P | OR8B8 | OR8D1 | OR8D2 | OR8D4 | OR8F1P | OR8G1 | OR8G2P | OR8G3P | OR8G5 | OR8G7P | OR8H1 | OR8H2 | OR8H3 | OR8I2 | OR8J1 | OR8J3 | OR8K1 | OR8K3 | OR8K5 | OR8S1 | OR8U1 | OR8U3 | OR8U8 | OR9A1P | OR9A2 | OR9A4 | OR9G1 | OR9G4 | OR9G9 | OR9H1P | OR9I1 | OR9K2 | OR9Q1 | OR9Q2 | ORAI1 | ORAI2 | ORAI3 | ORC1 | ORC2 | ORC3 | ORC4 | ORC5 | ORC6 | Orexin receptor | Organic anion transporters (OATs) | Organic cation transporter