OR8H3: A GPCR Involved in The Sense of Smell (G390152)

Target Name: OR8H3

NCBI ID: G390152

OR8H3: A GPCR Involved in The Sense of Smell

OR8H3 (Olfactory Receptor Family 8 Subfamily H Member 3) is a G protein-coupled receptor (GPCR) that is expressed in the olfactory system of the human nose. It is one of the six subfamilies of the OR8H gene family, which encodes for GPCRs that are involved in the sense of smell. OR8H3 is a 144 amino acid protein that is composed of a transmembrane domain and an extracellular loop.

The olfactory system is the system through which the sense of smell is detected and processed in the human nose. It is made up of a complex array of neurons and nerve cells that are responsible for transmitting signals from the sensory neurons to the brain. system is involved in the detection of a wide range of stimuli, including scents, flavors, and textures.

OR8H3 is one of the GPCRs that is involved in the sense of smell. It is a member of the OR8H gene family, which encodes for a family of GPCRs that are involved in the sense of smell. The OR8H gene family is one of the most well-studied GPCR families, with at least 12 known GPCRs that are involved in the sense of smell.

OR8H3 is a 144 amino acid protein that is composed of a transmembrane domain and an extracellular loop. The transmembrane domain of OR8H3 is responsible for maintaining the integrity of the protein and for interacting with other proteins. The extracellular loop of OR8H3 is responsible for the formation of the protein-ligand interaction, which is the process by which the protein interacts with its ligand.

OR8H3 is involved in the sense of smell by mediating the activation of olfactory nerve neurons. When a scent is applied to the olfactory system, it interacts with OR8H3 and triggers the activation of the olfactory nerve neurons. This activation leads to the transmission of signals to the brain, which results in the sensation of smell.

OR8H3 is also a potential drug target and biomarker. The olfactory system is a highly sensitive system that is involved in the detection of small changes in the environment. Therefore, drugs that can modulate the activity of OR8H3 could be useful for the treatment of various olfactory disorders, including odor disorders, axisitis, and basal olfactory cystitis.

In addition to its potential clinical applications, OR8H3 is also of interest to researchers as a study tool. The transmembrane and extracellular loop domains of OR8H3 make it an attractive target for study, as they are well-studied and are involved in the sense of smell . The use of antibodies that bind to OR8H3 could be used to study its function in the olfactory system, as well as its potential as a drug target.

In conclusion, OR8H3 (Olfactory Receptor Family 8 Subfamily H Member 3) is a GPCR that is involved in the sense of smell. It is a member of the OR8H gene family and is expressed in the olfactory system of the human nose. The transmembrane and extracellular loop domains of OR8H3 make it an attractive target for study, as they are well-studied and are involved in the sense of smell. The use of antibodies that bind to OR8H3 could be used to study its function in the olfactory system, as well as its potential as a drug target.

Protein Name: Olfactory Receptor Family 8 Subfamily H Member 3

Functions: Odorant receptor

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