OTULIN: A Protein Target for Cancer and Other Diseases (G90268)

Target Name: OTULIN

NCBI ID: G90268

OTULIN: A Protein Target for Cancer and Other Diseases

OTULIN (Ubiquitin thioesterase otulin) is a protein that is expressed in various tissues throughout the body, including muscle, liver, and heart. It plays a critical role in the regulation of protein stability and quality control. Mutations in the OTULIN gene have been linked to a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, OTULIN has emerged as a promising drug target and biomarker for a variety of diseases.

OTULIN functions as a protein complex component of the ubiquitin system, which is a protein-protein interaction network that plays a central role in regulating protein stability, localization, and degradation. The ubiquitin system is composed of several proteins, including OTULIN, which are involved in the covalent attachment of various protein partners to target proteins. OTULIN functions as the enzyme that adds the thioesterase active site to the ubiquitin molecule, which is critical for the covalent attachment of protein partners.

Mutations in the OTULIN gene have been linked to a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, mutations in the OTULIN gene have been linked to the development of various types of cancer, including breast, ovarian, and prostate cancer. In addition, mutations in the OTULIN gene have also been linked to a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

OTULIN has also been shown to play a role in the regulation of autoimmune disorders. For example, mutations in the OTULIN gene have been linked to the development of rheumatoid arthritis, a type of autoimmune disorder. In addition, OTULIN has also been shown to play a role in the regulation of inflammation, which is a critical aspect of autoimmune disorders.

In addition to its role in the regulation of protein stability and quality control, OTULIN has also been shown to play a variety of other roles in various tissues. For example, OTULIN is involved in the regulation of cell growth and differentiation, as well as the regulation of cell survival. In addition, OTULIN is also involved in the regulation of cell signaling pathways, including the regulation of cell proliferation and the development of cancer.

OTULIN has also been shown to play a role in the regulation of protein-protein interactions, which is critical for the regulation of various cellular processes. In addition, OTULIN is involved in the regulation of the ubiquitin code, which is the language of the ubiquitin system. This code is used to specify the specific sequence of amino acids that should be added to each target protein.

In conclusion, OTULIN is a protein that plays a critical role in the regulation of protein stability and quality control, as well as a variety of other cellular processes. Mutations in the OTULIN gene have been linked to a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, OTULIN has emerged as a promising drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of OTULIN in the regulation of protein stability and quality control, as well as its potential as a drug target and biomarker.

Protein Name: OTU Deubiquitinase With Linear Linkage Specificity

Functions: Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:26997266, PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327, PubMed:28919039, PubMed:35170849, PubMed:35587511). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (PubMed:23806334)

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