P4HA3: A Potential Drug Target and Biomarker for Prolyl 4-Hydroxylase Subunit Alpha 3

Target Name: P4HA3

NCBI ID: G283208

Other Name(s): Prolyl 4-hydroxylase subunit alpha 3, transcript variant 1 | collagen prolyl 4-hydroxylase alpha(III) | Prolyl 4-hydroxylase subunit alpha-3 | Prolyl 4-hydroxylase alpha III | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III | prolyl 4-hydroxylase, alpha polypeptide III | C-P4H{alpha}(III) | C-P4H alpha III | P4HA3 variant 1 | P4HA3_HUMAN | Procollagen-proline dioxygenase alpha 3 | Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3 | prolyl 4-hydroxylase subunit alpha 3 | 4-PH alpha-3 | Prolyl 4-hydroxylase subunit alpha-3 (isoform 1)

P4HA3: A Potential Drug Target and Biomarker for Prolyl 4-Hydroxylase Subunit Alpha 3

Introduction

Prolyl 4-hydroxylase subunit alpha 3 (P4HA3) is a protein that plays a crucial role in the regulation of protein homeostasis and is involved in the maintenance of cellular homeostasis. The P4HA3 gene has been identified as a potential drug target and biomarker for various diseases , including cancer, neurodegenerative disorders, and autoimmune diseases.

P4HA3 Functions as a Enzyme

P4HA3 is an enzyme that belongs to the family of serine proteins known as 2-oxidative phosphatases (Sirtuin). The primary function of P4HA3 is to catalyze the conversion of prolyl hydroxylation (PH) to 4-hydroxyproline (4-HP) using ATP and a small molecule inhibitor. This reaction is critical for the regulation of protein homeostasis and is a key step in the post-translational modification (PTM) pathway.

PH is a highly reactive amino acid that can modify the structure and function of proteins. The majority of PH transformations occur in the N-terminal or C-terminal regions of proteins, and these modifications play a crucial role in the regulation of protein stability, localization, and interactions. P4HA3 is specifically involved in the conversion of PH to 4-HP, which is a critical step in the PTM pathway.

P4HA3 as a Drug Target

The identification of P4HA3 as a potential drug target is based on its involvement in various cellular processes that are associated with the development and progression of various diseases. P4HA3 has been shown to be involved in the regulation of cell survival, apoptosis, and autophagy, as well as in the regulation of cellular signaling pathways.

Studies have shown that P4HA3 is involved in the regulation of cell survival and apoptosis. For example, P4HA3 has been shown to play a role in the regulation of cell cycle progression and apoptosis in various cancer cell lines. In addition, P4HA3 has been shown to be involved in the regulation of angiogenesis, a process that is critical for the development of new blood vessels that can provide oxygen and nutrients to tumor cells.

P4HA3 has also been shown to be involved in the regulation of cellular signaling pathways. For example, P4HA3 has been shown to play a role in the regulation of the PI3K/Akt signaling pathway, a pathway that is involved in the regulation of cell survival and growth. In addition, P4HA3 has been shown to play a role in the regulation of the TOR signaling pathway, a pathway that is involved in the regulation of cell growth and metabolism.

P4HA3 as a Biomarker

P4HA3 has also been shown to be involved in the regulation of various physiological processes that are critical for human health, including the regulation of inflammation, inflammation-reparative homeostasis (ITH), and cellular stress responses. For example, P4HA3 has been shown to play a role in the regulation of inflammation and inflammation-reparative homeostasis.

P4HA3 has been shown to play a role in the regulation of cellular stress responses. For example, P4HA3 has been shown to play a role in the regulation of cellular stress responses, including the regulation of inflammation and cellular apoptosis.

Conclusion

P4HA3 is an enzyme that is involved in the regulation of various cellular processes that are critical for human health. The identification of P4HA3 as a potential drug target and biomarker for various diseases makes it an attractive target for

Protein Name: Prolyl 4-hydroxylase Subunit Alpha 3

Functions: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins

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