PAGE4: A Potential Drug Target and Biomarker (G9506)

Target Name: PAGE4

NCBI ID: G9506

PAGE4: A Potential Drug Target and Biomarker

PAGE4, 鈥嬧?媠hort for PPAR未4, is a transcription factor that plays a crucial role in the regulation of lipid metabolism. It is a key regulator of lipid oxidation and has been implicated in various diseases, including obesity, diabetes, and cardiovascular disease.

The PAGE4 gene has four splice variants, PAGE4-1, PAGE4-2, PAGE4-3, and PAGE4-4. PAGE4-1 is the most abundant and has the highest expression level. PAGE4-2 and PAGE4-3 are less abundant and have lower expression levels, while PAGE4-4 is the least abundant and has the lowest expression level.

PAGE4 is a key regulator of lipid metabolism and has been shown to play a crucial role in the regulation of lipid oxidation. It is a transcriptional regulator that controls the expression of genes involved in lipid metabolism, including enzymes involved in lipid oxidation and metabolism.

In addition to its role in lipid metabolism, PAGE4 has also been shown to be involved in various signaling pathways. For example, it has been shown to be involved in the PI3K/Akt signaling pathway, which is involved in the regulation of cell signaling and survival.

Furthermore, PAGE4 has also been shown to be involved in the regulation of cellular processes that are important for the development and progression of various diseases, including cancer. For example, it has been shown to be involved in the regulation of cell adhesion and the migration of cancer cells.

In conclusion, PAGE4 is a potential drug target and biomarker that has been shown to play a crucial role in the regulation of various diseases. Further research is needed to fully understand its role in lipid metabolism and its potential as a drug target.

Protein Name: PAGE Family Member 4

Functions: Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN (PubMed:24263171, PubMed:28289210). Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway (PubMed:21357425, PubMed:25374899, PubMed:30658679)

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