PARP-6: A Non-Code RNA Molecule Regulating Gene Expression (G56965)

Target Name: PARP6

NCBI ID: G56965

PARP-6: A Non-Code RNA Molecule Regulating Gene Expression

PARP-6 (poly (A) rRNA-6) is a non-coding RNA molecule that plays a critical role in the regulation of gene expression in various organisms, including humans. PARP-6 is composed of two main subunits, PARP-6-A and PARP-6-B1, which give the molecule its unique structure.

The PARP-6 gene was first identified in 2007 and is located on chromosome 18q21. It is a member of the P Parama complex, which includes PPARs (poly (A) rRNA-like), PDBPs (poly (A) rRNA-binding proteins), and PPAR-AS (accessor protein 1). The PPAR-AS protein is a key regulator of the PARP-6 gene, and it is thought to play a role in the development and progression of various diseases, including cancer.

PARP-6 is involved in the regulation of gene expression by binding to specific DNA sequences and interacting with various proteins. It is well known for its role in the regulation of cell proliferation, apoptosis (programmed cell death), and DNA damage repair.

One of the unique features of PARP-6 is its ability to interact with the protein p53, which is a well-known regulator of DNA damage repair. Studies have shown that PARP-6 can bind to p53 and enhance its DNA-binding activity, leading to the regulation of gene expression and the promotion of cell proliferation.

In addition to its role in cell proliferation, PARP-6 is also involved in the regulation of cell apoptosis. Studies have shown that PARP-6 can interact with the protein Bcl-2 (B cell lymphoma 2) and promote its expression, leading to the regulation of cell apoptosis.

The role of PARP-6 in DNA damage repair is also of interest, as it is often disrupted in various diseases, including cancer. Studies have shown that PARP-6 can interact with the protein TRF2 (Telomere-replacement factor 2) and promote its expression, leading to the regulation of DNA damage repair and the maintenance of cellular telomeres.

PARP-6 is also involved in the regulation of gene expression in the immune system, which is of particular interest in the regulation of cancer cell immune surveillance. Studies have shown that PARP-6 can interact with the protein PDCD1 (protamineuronucleoside-dependent DNA damage-inducible gene 1) and promote its expression, leading to the regulation of cancer cell immune surveillance.

In conclusion, PARP-6 is a non-coding RNA molecule that plays a critical role in the regulation of gene expression in various organisms, including humans. Its unique structure and interactions with various proteins make it an attractive drug target and a potential biomarker for the development and progression of various diseases. Further research is needed to fully understand the role of PARP-6 in the regulation of gene expression and to develop effective treatments for its associated disorders.

Protein Name: Poly(ADP-ribose) Polymerase Family Member 6

Functions: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins

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