Prostate and Testis Protein 4 (PATE4) as A Drug Target and Biomarker

Target Name: PATE4

NCBI ID: G399968

Prostate and Testis Protein 4 (PATE4) as A Drug Target and Biomarker

Prostate and testis expressed protein 4 (PATE4) is a protein that is expressed in the prostate and testes, and it is also known as PAPR1 (proteinase-activated receptor 1). PATE4 is a 21-kDa protein that is characterized by its extracellular domain, which consists of a catalytic domain and a transmembrane domain.

The catalytic domain of PATE4 is composed of a single proteinase-activated loop (PAL) and a 尾-sheet. The PAL domain is the active site for proteinase-activation, and it is responsible for the catalytic activity of the protein. The 尾-sheet is the structural domain that gives PATE4 its unique structure and stability.

PATE4 is a key regulator of the prostate-specific antigen (PSA) gene, which is responsible for the production of the protein that is associated with prostate cancer. PATE4 is a negative regulator of the PSA gene, and it inhibits the translation of new PSA genes into protein.

In addition to its role in regulating PSA production, PATE4 is also involved in the regulation of testosterone synthesis and male sexual function. It is a key regulator of the conversion of androgens (such as testosterone) to estrogens, and it is also involved in the regulation of male sexual behavior.

PATE4 is a potential drug target for prostate and testicular cancer, as well as conditions related to testosterone levels. Studies have shown that inhibiting PATE4 can lead to the growth of prostate and testicular cancer cells, as well as the regression of androgens in male mice.

In addition to its potential as a drug target, PATE4 is also a potential biomarker for prostate and testicular cancer. The expression of PATE4 is often reduced in prostate and testicular cancer cells, and it has been used as a biomarker for these cancers in several studies.

One of the challenges in studying PATE4 is its expression in different tissues and organs, as well as its involvement in multiple signaling pathways. To better understand its role in these processes, researchers have used a variety of techniques, including RNA interference, overexpression, and biochemical assays.

In addition to its potential as a drug target and biomarker, PATE4 is also of interest to researchers as a potential therapeutic target for other conditions. For example, PATE4 has been shown to be involved in the regulation of fetal development and has been implicated in several diseases, including cancer, neurodegenerative diseases, and behavioral disorders.

In conclusion, PATE4 is a protein that is expressed in the prostate and testes and is involved in the regulation of PSA production and testosterone synthesis. It is a potential drug target and biomarker for prostate and testicular cancer, as well as conditions related to testosterone levels. Further research is needed to fully understand its role in these processes and its potential as a therapeutic target.

Protein Name: Prostate And Testis Expressed 4

Functions: May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility

More Common Targets