PCDHA12: A Potential Drug Target and Biomarker for Cardiovascular Disorders

Target Name: PCDHA12

NCBI ID: G56137

PCDHA12: A Potential Drug Target and Biomarker for Cardiovascular Disorders

PCDHA12 (Peripheral Capillary Dysplasia with Homologous Defect 12) is a genetic disorder that affects the development and function of blood vessels, particularly in the peripheral system. It is a autosomal-dominant disorder that is caused by a mutation in the PCDHA12 gene, which is located on chromosome 16.

PCDHA12 is a protein that is involved in the regulation of cell growth, differentiation, and survival. It is a transcription factor that is involved in the development and maintenance of blood vessels, as well as the regulation of angiogenesis (the formation of new blood vessels).

The PCDHA12 gene has been implicated in the development of a wide range of cardiovascular and neurological disorders, including peripheral artery disease, hypertension, and stroke. It is thought to be a drug target (or biomarker) for a variety of therapeutic approaches, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and stem cell transplantation.

PCDHA12 is a highly conserved gene that is expressed in a wide range of tissues and organs, including the brain, heart, kidneys, and intestines. It is thought to be involved in the regulation of cell proliferation, differentiation, and survival, and is expressed in a variety of cell types, including blood cells, epithelial cells, and smooth muscle cells.

The PCDHA12 gene has been implicated in the development of a wide range of cardiovascular and neurological disorders, including peripheral artery disease, hypertension, and stroke. It is thought to be a drug target (or biomarker) for a variety of therapeutic approaches, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and stem cell transplantation.

PCDHA12 is a protein that is involved in the regulation of cell growth, differentiation, and survival. It is a transcription factor that is involved in the development and maintenance of blood vessels, as well as the regulation of angiogenesis.

The PCDHA12 gene has been implicated in the development of a wide range of cardiovascular and neurological disorders, including peripheral artery disease, hypertension, and stroke. It is thought to be a drug target (or biomarker) for a variety of therapeutic approaches, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and stem cell transplantation.

In addition to its potential as a drug target, PCDHA12 is also a potential biomarker for the diagnosis and progression of cardiovascular and neurological disorders. Studies have shown that PCDHA12 levels are often elevated in individuals with cardiovascular disease, and that levels are also decreased in individuals after stroke. This suggests that PCDHA12 may be a useful diagnostic or predictive marker for these disorders.

Furthermore, some studies have suggested that PCDHA12 may be involved in the regulation of angiogenesis, the process by which new blood vessels are formed. This suggests that PCDHA12 may be a potential target for therapies that are aimed at enhancing or inhibiting the formation of new blood vessels.

In conclusion, PCDHA12 is a protein that is involved in the regulation of cell growth, differentiation, and survival. It is a transcription factor that is involved in the development and maintenance of blood vessels, as well as the regulation of angiogenesis. The PCDHA12 gene has been implicated in the development of a wide range of cardiovascular and neurological disorders, including peripheral artery disease, hypertension, and stroke. It is thought to be a drug target (or biomarker) for a variety of therapeutic approaches, including angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and stem cell transplantation. Furthermore, some studies have suggested that PCDHA12 may be involved in the regulation of angiogenesis, the process by which new blood vessels are formed. Further research is needed to fully understand the role of PCDHA12 in the development and progression of cardiovascular and neurological disorders.

Protein Name: Protocadherin Alpha 12

Functions: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

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