PARP4: A Potential Drug Target and Biomarker for Cancer (G143)

Target Name: PARP4

NCBI ID: G143

PARP4: A Potential Drug Target and Biomarker for Cancer

PARP4 (Poly(ADP-ribose) polymerase 4) is a enzyme that plays a crucial role in the regulation of DNA damage repair.PARP4 is a member of the poly(ADP-ribose) polymerase (PARP) family, which also includes PARP1 and PARP2.PARP4 is expressed in most tissues and is involved in the repair of a wide range of DNA damage types, including double-strand breaks, single-strand breaks, and insertions/deletions.

One of the significant features of PARP4 is its ability to generate high-fidelity repair templates.PARP4 has been shown to generate templates that are completely compatible with those produced by PARP1 and PARP2, indicating that it can function as a scaffold to facilitate the repair of DNA damage.

In addition to its role in DNA damage repair, PARP4 is also a potential drug target.PARP4 has been shown to be involved in the regulation of cellular processes that are important for cancer progression, including cell division, apoptosis, and angiogenesis.

PARP4 has also been shown to be involved in the regulation of inflammation, and has been shown to play a role in the development of certain types of cancer.

PARP4 is also a potential biomarker for certain types of cancer.PARP4 has been shown to be expressed in a wide range of cancer types, including breast, ovarian, and colorectal cancers.

In addition to its potential clinical applications, PARP4 is also an important research tool for scientists studying the role of PARP4 in cellular processes.PARP4 has been extensively studied using a variety of techniques, including RNA sequencing, transcriptomics, and immunofluorescence.

Overall, PARP4 is a complex and important enzyme that plays a crucial role in the regulation of DNA damage repair.PARP4 is also a potential drug target and biomarker for a wide range of cancer types. Further research is needed to fully understand the role of PARP4 in cellular processes and its potential as a therapeutic target.

Protein Name: Poly(ADP-ribose) Polymerase Family Member 4

Functions: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins

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