Pacsin1: A Potential Drug Target and Biomarker for Neuronal Signaling

Target Name: PACSIN1

NCBI ID: G29993

Pacsin1: A Potential Drug Target and Biomarker for Neuronal Signaling

PACSIN1, also known as Protein Kinase C (PKC) and Casein Kinase Substrate (CKS), is a protein that plays a crucial role in neuronal signaling. It is a non-cysteine-rich C-terminal protein that contains a single transmembrane domain and a unique N-terminus. PACSIN1 is highly conserved across various species, and its identity has been confirmed through various bioinformatics and biochemical studies. PACSIN1 is often expressed in a variety of neural tissues, including brain, spinal cord, and peripheral tissues.

PACSIN1 functions as a protein kinase, which is a type of enzyme that adds a phosphate group to the protein target. This phosphorylation event can modulate the activity and stability of the target protein, and it is involved in a wide range of cellular processes, including intracellular signaling, cell adhesion, migration, and survival. PACSIN1 is known to play a key role in the regulation of neuronal signaling by tyrosine kinases, which are important targets for many pharmaceuticals.

PACSIN1 is a potential drug target because of its involvement in neuronal signaling. Many neurotransmitters, including proteins that regulate synaptic transmission, neurotrophic factors, and cytokines, can be targeted by tyrosine kinases. PACSIN1 is known to be involved in the regulation of neurotransmitter signaling, which suggests that it may be a useful target for drugs that target neurotransmitter receptors. Additionally, PACSIN1 is involved in the regulation of cell survival and has been shown to play a role in neuroprotection.

PACSIN1 is also a potential biomarker for some neurological disorders. For example, PACSIN1 has been shown to be overexpressed in certain neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Additionally, high levels of PACSIN1 have been shown to be associated with increased risk of certain neurological injuries, such as Traumatic Brain Injury (TBI) and Stroke.

PACSIN1 is a unique protein that is involved in a wide range of cellular processes. Its function as a protein kinase makes it an attractive target for drugs that target neurotransmitter receptors, and its involvement in neuronal signaling and cell survival make it a potential biomarker for some neurological disorders. Further research is needed to fully understand the role of PACSIN1 in cellular signaling and its potential as a drug target and biomarker.

Protein Name: Protein Kinase C And Casein Kinase Substrate In Neurons 1

Functions: Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation

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