OSMR: Key Regulator of Inflammation, Cell Proliferation and Eye Development

Target Name: OSMR

NCBI ID: G9180

OSMR: Key Regulator of Inflammation, Cell Proliferation and Eye Development

OSMR (Interleukin-31 Receptor Subunit Beta) is a protein that is expressed in various tissues throughout the body, including the skin, hair, and eyes. It is a member of the interleukin-31 receptor subfamily, which is a family of cytokines that play a crucial role in the regulation of cellular processes such as inflammation, proliferation, and differentiation.

OSMR is a 21-kDa protein that is composed of two distinct subunits, alpha and beta. The alpha subunit consists of 121 amino acids, while the beta subunit consists of 55 amino acids. Both subunits contain a unique catalytic domain that is responsible for the protein's unique structure and function.

One of the key functions of OSMR is its role in the regulation of inflammation. During inflammation, OSMR helps to coordinate the response of immune cells to the infection or injury. It does this by interacting with other proteins that are involved in the immune response, including the nuclear factor kappa B (NF-kappa-B) receptor.

NF-kappa-B is a protein that is involved in the regulation of a wide range of cellular processes, including inflammation, DNA damage, and cell survival. It is composed of four subunits, including an alpha subunit, an beta subunit, a gamma subunit, and a delta subunit. The gamma subunit is the most abundant of the subunits, and it is responsible for interacting with OSMR to regulate the activity of the NF-kappa-B receptor.

OSMR's interaction with NF-kappa-B is critical for the regulation of inflammation because NF-kappa-B is involved in the recruitment of immune cells to the site of inflammation. By interacting with OSMR, the gamma subunit of NF-kappa-B can activate the beta subunit of OSMR , which in turn can cause the activation of NF-kappa-B. This activation of NF-kappa-B leads to the production of pro-inflammatory cytokines, such as TNF-伪, IL-1尾, and IL-6, which contribute to the inflammation that follows an injury or infection.

Another function of OSMR is its role in the regulation of cell proliferation. OSMR has been shown to play a negative role in the regulation of cell proliferation, and it has been shown to inhibit the activity of the TGF-β1 signaling pathway. TGF-β1 is a cytokine that is involved in the regulation of cell proliferation, and OSMR has been shown to inhibit the production of TGF-β1 by stem cells.

OSMR's negative impact on cell proliferation is critical because it helps to prevent the uncontrolled growth and transformation of cancer cells. The proliferation of cancer cells is one of the important reasons for the occurrence and development of cancer, and OSMR's role in inhibiting cell proliferation is a key part of its anti-cancer function.

In addition to its role in the regulation of inflammation and cell proliferation, OSMR has also been shown to play a role in the regulation of eye development and function. OSMR is a key regulator of the development and maintenance of the retina, and it has been shown to play a role in the regulation of the structure and function of the retina.

OSMR's role in eye development and function is critical because it helps to ensure that the retina is properly formed and functioned. The retina is responsible for providing the visual system with the information it needs to allow us to see the world around us, and any abnormalities in its structure or function can lead to a wide range of vision problems.

Finally, OSMR has also been shown to have potential as a drug target. Its unique structure and function, as well as its involvement in the regulation of inflammation, cell proliferation, and eye development, make it an attractive target for

Protein Name: Oncostatin M Receptor

Functions: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events

More Common Targets