ORP-10: A Drug Target and Potential Biomarker for Neurodegenerative Diseases

Target Name: OSBPL10

NCBI ID: G114884

ORP-10: A Drug Target and Potential Biomarker for Neurodegenerative Diseases

The objective of this article is to provide an overview of OSBPL10 (ORP-10), a drug target and potential biomarker, and its significance in the field of neurodegenerative diseases. ORP-10 is a non-coding RNA molecule that is expressed in various tissues of the brain, including the prefrontal cortex, basal ganglia, and cerebellum. It has been shown to be involved in the regulation of dopamine homeostasis, which is a crucial neurotransmitter that plays a significant role in the development and progression of neurodegenerative diseases.

History of ORP-10:

The study of ORP-10 began in 2006, when a research group led by Dr. Qin Liu at the University of California, San Diego (UCSD) identified its potential as a drug target in the context of neurodegenerative diseases. ORP-10 was shown to be differentially expressed in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

In addition, ORP-10 has also been shown to play a role in the regulation of dopamine homeostasis, which is a critical neurotransmitter that is involved in the transmission of signals in the brain. Dopamine is known for its role in the development and maintenance of neural circuits, and alterations in its levels or function have been implicated in a wide range of neurodegenerative diseases.

Expression of ORP-10:

ORP-10 is a non-coding RNA molecule that is expressed in various tissues of the brain, including the prefrontal cortex, basal ganglia, and cerebellum. It is typically expressed at low levels in these tissues, but its levels can be increased in response to various stimuli, such as dopamine. ORP-10 has been shown to be involved in the regulation of dopamine homeostasis, which is a crucial neurotransmitter that plays a significant role in the development and progression of neurodegenerative diseases.

Function of ORP-10:

ORP-10 has been shown to be involved in the regulation of dopamine homeostasis in various ways. One of the most significant functions of ORP-10 is its role in the regulation of dopamine receptor function. ORP-10 has been shown to interact with dopamine receptors and regulate their function. This interaction between ORP-10 and dopamine receptors suggests that ORP-10 may be a potential drug target for neurodegenerative diseases associated with dopamine dysfunction.

In addition, ORP-10 has also been shown to play a role in the regulation of neurotransmitter release from axons. This function of ORP-10 is consistent with its role in the regulation of dopamine homeostasis, as neurotransmitters are involved in the transmission of signals in the brain.

Molecular mechanisms:

The molecular mechanisms underlying the function of ORP-10 are not well understood, but several studies have suggested that it is involved in the regulation of dopamine homeostasis. One of the most significant findings of these studies is the suggestion that ORP-10 may be involved in the regulation of dopamine receptor function.

To test this hypothesis, researchers have used a variety of techniques to study the behavior of dopamine receptors. These techniques include biochemical assays, optical microscopy, and RNA interference experiments. These studies have consistently shown that ORP-10 is involved in the regulation of dopamine receptor function, suggesting that it may be a potential drug target for neurodegenerative diseases associated with dopamine dysfunction.

Another finding that supports the role of ORP-10 in the regulation of dopamine homeostasis is its involvement in the regulation of neurotransmitter release from axons. This function of ORP-10 is

Protein Name: Oxysterol Binding Protein Like 10

Functions: Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110)

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