SMAD3: Key Regulator of Tissue Development and Maintenance (G4088)

Target Name: SMAD3

NCBI ID: G4088

SMAD3: Key Regulator of Tissue Development and Maintenance

SMAD3, also known as mad homolog JV15-2, is a protein that is expressed in many tissues throughout the body. It is a key regulator of cell growth and differentiation, and is involved in the development and maintenance of tissues such as hair, nails, and bones. SMAD3 has also been shown to play a role in the regulation of cellular processes such as cell death, angiogenesis, and inflammation.

SMAD3 is a member of the SMAD family of proteins, which are known for their ability to regulate gene expression. SMAD3 is composed of 215 amino acid residues and has a calculated molecular weight of 21.1 kDa. It is expressed in a variety of tissues, including hair follicles, nail growth sites, skin, heart, and brain.

SMAD3 is involved in the regulation of several key cellular processes that are important for tissue development and maintenance. One of its main functions is to regulate cell growth and differentiation. SMAD3 has been shown to play a role in the regulation of cell proliferation, and is involved in the development of cancer.

SMAD3 is also involved in the regulation of cell death. When a cell reaches the end of its life, SMAD3 helps to ensure that it undergoes a process of programmed cell death, known as apoptosis. This is important for the regulation of tissue homeostasis and for the maintenance of tissue repair.

SMAD3 is also involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed. This is important for the development and maintenance of tissues such as blood vessels, hearts, and lungs.

SMAD3 has also been shown to play a role in the regulation of inflammation. It is involved in the regulation of the immune response and has been shown to play a role in the regulation of chronic inflammation.

SMAD3 is also a potential drug target. Its role in the regulation of cell growth and differentiation makes it an attractive target for the development of new therapies for a variety of diseases.

In addition to its role in cell growth and differentiation, SMAD3 has also been shown to play a role in the regulation of cellular processes such as cell death, angiogenesis, and inflammation. This makes it an attractive target for the development of new therapies for a variety of diseases.

Overall, SMAD3 is a protein that is involved in a variety of cellular processes that are important for tissue development and maintenance. Its role in these processes makes it an attractive target for the development of new therapies for a variety of diseases. Further research is needed to fully understand the role of SMAD3 in these processes and to develop new treatments.

Protein Name: SMAD Family Member 3

Functions: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator

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