SMKR1: A Drug Target / Disease Biomarker (G100287482)

Target Name: SMKR1

NCBI ID: G100287482

Other Name(s): Small lysine-rich protein 1 | Small lysine rich protein 1 | SMKR1_HUMAN | small lysine rich protein 1

SMKR1: A Drug Target / Disease Biomarker

SMKR1, short for small molecule kinase receptor 1, is a protein that is expressed in various tissues throughout the body. It is a member of the SMK family of kinases, which are a group of transmembrane proteins that play a crucial role in cellular signaling. SMKR1 is known for its role in the regulation of cellular processes such as cell growth, differentiation, and survival.

SMKR1 has been identified as a potential drug target in the pharmaceutical industry due to its involvement in a variety of cellular processes that are often disrupted in diseases such as cancer, neurodegenerative diseases, and autoimmune disorders. Additionally, its unique structure and subcellular localization have made it an attractive target for small molecule inhibitors.

SMKR1 is a 21-kDa protein that is expressed in various tissues, including brain, heart, liver, and muscle. It is highly conserved, with a calculated pI of 11.0 and a predicted localization in the cytoplasm. SMKR1 has four known isoforms, which are different in their size and distribution.

SMKR1 is involved in a variety of cellular processes that are critical for cell survival and growth. One of its main functions is to regulate cell proliferation. SMKR1 has been shown to play a negative role in the growth of various cancer cell lines, and to promote cell cycle arrest in response to growth inhibitors.

SMKR1 is also involved in the regulation of cell differentiation and plasticity. It has been shown to be involved in the regulation of stem cell proliferation and the maintenance of stem cell stem cell properties. Additionally, SMKR1 has been shown to play a role in the regulation of neurogenesis, and to be involved in the development of neural stem cells.

SMKR1 is also involved in the regulation of cell survival and stress resistance. It has been shown to play a role in the regulation of apoptosis, and to be involved in the stress response. Additionally, SMKR1 has been shown to be involved in the regulation of autophagy, and to play a role in the maintenance of cellular homeostasis.

SMKR1 has also been identified as a potential biomarker for a variety of diseases. For example, it has been shown to be involved in the regulation of cancer cell metastasis, and to be expressed in the brains of patients with Alzheimer's disease. Additionally, SMKR1 has been shown to be involved in the regulation of immune cell function, and to be involved in the development of autoimmune diseases.

In conclusion, SMKR1 is a protein that is involved in a variety of cellular processes that are critical for cell survival and growth. Its unique structure and subcellular localization make it an attractive target for small molecule inhibitors, and its involvement in a variety of diseases make it a promising drug target. Further research is needed to fully understand the role of SMKR1 in cellular processes and its potential as a drug target.

Protein Name: Small Lysine Rich Protein 1

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