SMOC2: A Potential Drug Target for Various Diseases (G64094)

Target Name: SMOC2

NCBI ID: G64094

SMOC2: A Potential Drug Target for Various Diseases

SMOC2 (SMAP-2), a protein that belongs to the family of water-type transmembrane proteins (WTPs), has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function have made it an attractive target for researchers to study and develop new treatments.

SMOC2 is a 21-kDa protein that is expressed in various tissues and cells in the body. It is localized to the endoplasmic reticulum (ER) and appears to play a critical role in regulating the transport of molecules across the ER membrane. SMOC2 functions as a transmembrane protein by forming a water-type channel that allows specific molecules to enter or exit the ER. This channel is composed of four transmembrane domains: an N-terminal alpha-helix, a transmembrane domain, a src-like domain, and a C-terminal beta-sheet.

SMOC2 is a unique protein because of its ability to form a stable and functional channel that is selective for certain molecules. For example, it is able to allow inositol and anions to pass through its channel, but not water or other large molecules. This selectivity is important for the function of the channel, as it allows the cell to maintain a stable internal environment and avoids the formation of large channels that could disrupt the cell's normal functions.

SMOC2 has also been shown to play a role in various cellular processes, including intracellular signaling, cell survival, and the regulation of ion channels. For example, studies have shown that SMOC2 is involved in the regulation of neurotransmitter release from neurons, which is important mood for various neural functions, including regulation, learning, and movement. Additionally, SMOC2 has been shown to play a role in the regulation of cell survival, as it has been shown to protect against various forms of cellular stress, such as oxidative stress and apoptosis.

SMOC2 has also been shown to be involved in the regulation of ion channels in various tissues and cells. For example, studies have shown that SMOC2 is involved in the regulation of sodium (Na+) channels in the heart, which are important for maintaining normal heart function. Additionally, SMOC2 has been shown to be involved in the regulation of potassium (K+) channels in the brain, which are important for maintaining normal brain function.

In addition to its role in cellular signaling, SMOC2 has also been shown to have potential as a drug target. Its unique structure and function make it an attractive target for small molecules, which can be used to modulate its activity and inhibit its function. This has led to a growing interest in the development of SMOC2-targeted drugs for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

SMOC2 has been shown to have potential as a cancer drug target by its ability to promote the growth and survival of cancer cells. Studies have shown that SMOC2 is involved in the regulation of various cellular processes that are important for cancer cell growth, including the regulation of cell cycle progression, angiogenesis, and the production of signaling molecules. Additionally, SMOC2 has been shown to promote the migration and invasion of cancer cells, which is a key step in the development of cancer.

SMOC2 has also been shown to have potential as a neurodegenerative disease drug target by its ability to contribute to the progression of neurodegenerative diseases. Studies have shown that SMOC2 is involved in the regulation of various cellular processes that are important for the development and progression of neurodegenerative diseases, including the regulation of neurotransmitter release, axon growth, and the regulation of cellular stress. Additionally, SMOC2 has

Protein Name: SPARC Related Modular Calcium Binding 2

Functions: Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis

More Common Targets