SMURF1: A Ubiquitin Protein with Potential as A Drug Target Or Biomarker

Target Name: SMURF1

NCBI ID: G57154

SMURF1: A Ubiquitin Protein with Potential as A Drug Target Or Biomarker

SMURF1 (Smuchenin-like module 1) is a protein that belongs to the ubiquitin family of proteins. It is a key regulator of cell division and has been implicated in a wide range of cellular processes, including the regulation of DNA replication, the association with histone modification, and the control of cell growth. In recent years, researchers have been increasingly interested in SMURF1 as a potential drug target or biomarker, due to its unique structure and the involvement of several key cellular processes.

The ubiquitin family of proteins is a large and diverse group of proteins that play a critical role in cellular signaling and regulation. These proteins are made up of a series of amino acid residues that are held together by a special bond called a disulfide. This bond is formed by the formation of a disulfide bond between two amino acids, which is then followed by a second bond that is formed between the carboxylic acid and the amino acid on the other side of the disulfide.

SMURF1 is a type of ubiquitin protein that is characterized by its unique structure. It consists of a long amino acid sequence that is rich in charged residues, such as Asp and Glu. This charged sequence is known as a \"smuchenin-like module, \" and it gives SMURF1 its unique name.

SMURF1 is involved in a wide range of cellular processes, including the regulation of cell division, the association with histone modification, and the control of cell growth. One of the key functions of SMURF1 is its role in the regulation of DNA replication. SMURF1 has has been shown to play a critical role in the regulation of the DNA double helix, by helping to ensure that the correct number of histone copies are attached to each replication complex.

In addition to its role in DNA replication, SMURF1 is also involved in the regulation of cell growth. It has been shown to play a key role in the regulation of cell growth by inhibiting the activity of the oncogene transforming growth factor-尾 (TGF- 尾), which is a key regulator of cell growth.

SMURF1 has also been shown to be involved in the regulation of histone modification. Histone modification is a process by which proteins are modified with chemical groups, such as acetyl groups, to changes their stability and localization in the cell. of histone modification by the addition of acetyl groups to the histones, which is a critical step in the process.

In conclusion, SMURF1 is a unique and highly versatile protein that is involved in a wide range of cellular processes. Its unique structure and the involvement of several key cellular processes make it an attractive candidate as a drug target or biomarker. Further research is needed to fully understand the role of SMURF1 in cellular signaling and regulation.

Protein Name: SMAD Specific E3 Ubiquitin Protein Ligase 1

Functions: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation (PubMed:21791611). Plays a role in dendrite formation by melanocytes (PubMed:23999003)

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