SMAD9: A Non-Coding RNA Molecule with Broad Functions and Potential as A Drug Target

Target Name: SMAD9

NCBI ID: G4093

SMAD9: A Non-Coding RNA Molecule with Broad Functions and Potential as A Drug Target

SMAD9 (SMAD8B) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for various diseases, including cancer. Its unique structure and function have made it an attractive target for researchers to study, and recent studies have shed light on its role in various biological processes.

SMAD9 is a member of the SMAD family, which includes four proteins that are involved in the regulation of gene expression. The SMAD family has been shown to play a crucial role in the development and progression of various diseases, including cancer. SMAD9 is a non -coding RNA molecule that has been shown to interact with the SMAD2 protein, which is a key regulator of gene expression in many cell types.

One of the key functions of SMAD9 is its ability to recruit other RNA molecules into its folded structure. By binding to other RNA molecules, SMAD9 can regulate gene expression, thereby affecting a variety of biological processes. These interactions make SMAD9 play an important role in cell biology.

In addition, SMAD9 also plays an important role in tumorigenesis and progression. Studies have shown that SMAD9 is expressed at different levels in multiple tumor types and that its expression levels are positively correlated with tumor aggressiveness and prognosis. These findings provide important clues for studying SMAD9 as a target for tumor treatment.

Another function of SMAD9 is its effect on the cell cycle. Studies have shown that SMAD9 is expressed in the S phase and G phase of the cell cycle, and is significantly increased in the S phase of the cell cycle. These findings indicate that SMAD9 plays an important role in the cell cycle and may be related to cell cycle regulation.

In addition, SMAD9 is also closely related to the occurrence and development of some diseases. For example, studies have shown that SMAD9 is upregulated in various neurological diseases such as Alzheimer's disease and Parkinson's disease, and these diseases are closely related to neuronal death and degeneration.

SMAD9 does more than that. Some studies suggest that SMAD9 plays an important role in the immune system. Research shows that SMAD9 plays a role in T cell development and activation and also plays an important role in immune responses.

Taken together, SMAD9 is a molecule with broad effects and unique properties. Its function and structure make it a promising drug target. By further studying SMAD9, its role in biological processes can be revealed and more effective treatments developed.

Protein Name: SMAD Family Member 9

Functions: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD)

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