Target Name: NFIB
NCBI ID: G4781
Other Name(s): Nuclear factor 1 B-type isoform 5 | NF1-B | NF-I/B | NFI-B | TGGCA-binding protein | Nuclear factor 1/B | nuclear factor 1/B | HMGIC/NFIB | Nuclear factor I B, transcript variant 1 | Nuclear factor I/B (NFIB) | NFIB variant 1 | Nuclear factor I/B | Nuclear factor 1 B-type | NFIB_HUMAN | NFIB variant 5 | Nuclear factor 1 B-type (isoform 1) | CCAAT-box-binding transcription factor | Nuclear factor I B, transcript variant 5 | NFIB2 | NFIB3 | nuclear factor I B | MACID | NFI-RED | CTF

NF1 Plays A Crucial Role in Regulating Hematopoietic Stem Cell Proliferation

Nuclear factor 1 (NF1) is a transcription factor, which plays a crucial role in the regulation of gene expression. It is composed of two isoforms, B-type and I-type. The B-type isoform is a key regulator of hematopoietic stem cell (HSC) proliferation and differentiation, while the I-type isoform is involved in the development and maintenance of tissues such as the liver and nervous system.

NF1 has been implicated in the development and progression of many diseases, including leukemia, lymphoma, and neuroblastoma. It has also been implicated in the regulation of stem cell proliferation and the development of tissues.

One of the key challenges in studying NF1 is its complex structure and function. The B-type isoform of NF1 is a 21-kDa protein that contains a N-terminal domain, a catalytic domain, and a C-terminal domain. The terminal domain contains a nuclear localization signal and is involved in the interaction with DNA. The catalytic domain contains a zinc ion site and is involved in the regulation of DNA binding. The C-terminal domain contains a hinge region and is involved in the regulation of protein-protein interactions.

The B-type isoform of NF1 has been shown to play a crucial role in the regulation of hematopoietic stem cell (HSC) proliferation and differentiation. It is expressed in the stem cells and has been shown to promote the growth and proliferation of HSCs in culture . The B-type isoform has also been shown to play a role in the regulation of the stem cell expansion and self-renewal.

In addition to its role in HSCs, the B-type isoform of NF1 has also been shown to play a role in the regulation of tissues such as the liver and nervous system. It is expressed in the liver and has been shown to play a role in the regulation of liver regeneration and metabolism. It is also expressed in the nervous system and has been shown to play a role in the regulation of neural stem cell proliferation and differentiation.

The I-type isoform of NF1 is a 24-kDa protein that contains a N-terminal domain, a catalytic domain, and a C-terminal domain. The N-terminal domain contains a nuclear localization signal and is involved in the interaction with DNA . The catalytic domain contains a zinc ion site and is involved in the regulation of DNA binding. The C-terminal domain contains a hinge region and is involved in the regulation of protein-protein interactions.

The I-type isoform of NF1 has been shown to be involved in the regulation of stem cell proliferation and the development of tissues. It is expressed in the stem cells and has been shown to promote the growth and proliferation of stem cells in culture. I-type isoform has also been shown to play a role in the regulation of the stem cell expansion and self-renewal.

In addition to its role in stem cells, the I-type isoform of NF1 has also been shown to play a role in the regulation of tissues such as the brain and heart. It is expressed in the brain and has been shown to play a role in the regulation of neural stem cell proliferation and differentiation. It is also expressed in the heart and has been shown to play a role in the regulation of cardiac stem cell proliferation and differentiation.

The B-type isoform of NF1 has been shown to play a crucial role in the regulation of hematopoietic stem cell (HSC) proliferation and differentiation. It is expressed in the stem cells and has been shown to promote the growth and proliferation of HSCs in culture . The B-type isoform has also been shown to play

Protein Name: Nuclear Factor I B

Functions: Transcriptional activator of GFAP, essential for proper brain development (PubMed:30388402). Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication

More Common Targets

NFIC | NFIL3 | NFILZ | NFIX | NFKB1 | NFKB2 | NFKBIA | NFKBIB | NFKBID | NFKBIE | NFKBIL1 | NFKBIZ | NFRKB | NFS1 | NFU1 | NFX1 | NFXL1 | NFYA | NFYAP1 | NFYB | NFYC | NFYC-AS1 | NFYCP2 | NGB | NGDN | NGEF | NGF | NGFR | NGFR-AS1 | NGLY1 | NGRN | NHEG1 | NHEJ1 | NHERF1 | NHERF2 | NHERF4 | NHLH1 | NHLH2 | NHLRC1 | NHLRC2 | NHLRC3 | NHLRC4 | NHP2 | NHP2P1 | NHS | NHSL1 | NHSL1-AS1 | NHSL2 | NIBAN1 | NIBAN2 | NIBAN3 | Nicalin-NOMO complex | NICN1 | Nicotinic (alpha4beta2)2alpha4 receptor | Nicotinic (alpha4beta2)2beta2 receptor | Nicotinic alpha1beta1deltaepsilon Receptor | Nicotinic alpha1beta1deltagamma Receptor | Nicotinic alpha3alpha6beta2 Receptor | Nicotinic alpha3beta2 receptor | Nicotinic alpha3beta2beta3 receptor | Nicotinic alpha3beta4 Receptor | Nicotinic alpha4beta2 receptor | Nicotinic alpha4beta2alpha5 Receptor | Nicotinic alpha4beta4 receptor | Nicotinic alpha6alpha3beta2 Receptor | Nicotinic alpha6alpha3beta2beta3 receptor | Nicotinic alpha6beta2alpha4beta2beta3 receptor | Nicotinic alpha6beta2beta3 receptor | Nicotinic alpha6beta4beta3alpha5 receptor | Nicotinic alpha9alpha10 Receptor | NID1 | NID2 | NIF3L1 | NIFK | NIFK-AS1 | NIHCOLE | NIM1K | NIN | NINJ1 | NINJ2 | NINJ2-AS1 | NINL | NIP7 | NIPA1 | NIPA2 | NIPAL1 | NIPAL2 | NIPAL3 | NIPAL4 | NIPBL | NIPBL-DT | NIPSNAP1 | NIPSNAP2 | NIPSNAP3A | NIPSNAP3B | NISCH | NIT1 | NIT2 | Nitric oxide synthase (NOS) | NKAIN1