NF-YB: A Protein Target for Drug Development (G4801)

Target Name: NFYB

NCBI ID: G4801

NF-YB: A Protein Target for Drug Development

NFYB, or neurofilament subunit, is a protein that plays a crucial role in the development and maintenance of neural circuits in the brain. It is a transcription factor that is expressed in a wide range of tissues, including neurons, glial cells, and other neural cell types. NFYB has been implicated in a number of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. As a result, it has become an attractive target for drug development.

The NF-Y family of proteins is characterized by a conserved N-terminal domain, a unique feature that is found in all of the proteins in this family. This domain is responsible for NF-Y's ability to interact with DNA and for regulating gene expression. The NF-YB subunit is a 21-kDa protein that is composed of two distinct subunits, a long N-terminal subunit (NF-YB伪) and a smaller B subunit.

The NF-YB伪 subunit is the most well-studied subunit, and its function is similar to that of its human counterpart, NF-YB尾. Both subunits contain a number of conserved amino acids that are involved in the formation of a protein-ligand complex with DNA. This complex is necessary for NF-YB to interact with the double helix and to regulate gene expression.

One of the key features of NF-YB is its ability to form a stable protein-ligand complex with DNA. This complex is formed through a process called DNA binding, which is regulated by a number of factors, including the strength of the DNA-binding domain and the presence of other protein subunits. Once the DNA-binding domain is engaged, NF-YB伪 is able to form a stable complex with the DNA, allowing the subunit to interact with the double helix and to regulate gene expression.

The ability of NF-YB to form a stable DNA-binding complex is what makes it such an attractive target for drug development. By blocking the activity of NF-YB, researchers can prevent the regulation of gene expression and disrupt the neural circuits that are responsible for a wide range of physiological processes. This can lead to the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

NF-YB has also been implicated in a number of psychiatric disorders, including depression and schizophrenia. Studies have suggested thatNF-YB may play a role in the regulation of neurotransmitter synthesis and release, as well as the modulation of ion channels in the brain. It is also possible that NF-YB may be involved in the regulation of neuronal excitability and synaptic plasticity, which are critical for the development and maintenance of neural circuits.

In conclusion, NF-YB is a protein that is expressed in a wide range of tissues and is involved in the development and maintenance of neural circuits in the brain. Its ability to form a stable protein-ligand complex with DNA makes it an attractive target for drug development, and its involvement in a number of neurological and psychiatric disorders makes it a valuable biomarker for diagnostic and therapeutic applications. Further research is needed to fully understand the role of NF-YB in neural development and function, and to develop effective treatments for the disorders associated with its dysfunction.

Protein Name: Nuclear Transcription Factor Y Subunit Beta

Functions: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors

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