Sodium/Potassium-Transporting ATPase Beta-3 Chain: A Promising Drug Target and Biomarker

Target Name: ATP1B3

NCBI ID: G483

Sodium/Potassium-Transporting ATPase Beta-3 Chain: A Promising Drug Target and Biomarker

Introduction

ATP (adenylyl cyclic phosphate) is the primary energy source for most eukaryotic cells. The transport of ATP across cell membranes is critical for maintaining cellular energy homeostasis, and various transporters, including the sodium/potassium-transporting ATPase (ATPase灏?3), play a crucial role in this process. Mammalian ATPase灏?3 is a member of the ATPase subfamily, which includes four structurally similar subunits: 灏?1, 灏?2, 灏?3, and 灏?4. The 灏?3 subunit is the most abundant and widely expressed subunit, and it plays a vital role in regulating sodium and potassium transport across cell membranes.

Sodium/potassium-transporting ATPase灏?3 is a critical protein that helps maintain the resting membrane potential of most eukaryotic cells. It is a transmembrane protein that spans the outer membrane of the mitochondria and the endoplasmic reticulum (ER). The 灏?3 subunit is responsible for driving the ATP-dependent sodium and potassium transport across the endoplasmic reticulum (ER) and maintaining the cytosolic concentration of these ions.

Several studies have identified potential drug targets and biomarkers associated with the sodium/potassium-transporting ATPase灏?3. One of the most promising targets is the BH-3 complex, which is a key regulator of ATPase灏?3 function. The BH-3 complex is a protein complex that contains the 灏?1 subunit of ATPase灏?3, as well as the protein SIRT1 (Sirtuin), which is known to interact with ATPase灏?3 and modulate its activity.

Drugs that target the BH-3 complex or its components have the potential to treat various neurological and cardiovascular disorders, including Alzheimer's disease, Parkinson's disease, and heart failure. Moreover, the BH-3 complex is also a potential biomarker for evaluating the efficacy of such drugs.

Another potential drug target associated with ATPase灏?3 is the Ca2+-ATPase, which is a calcium-dependent enzyme that is involved in regulating various cellular processes, including muscle contraction, neural transmission, and inflammation. The Ca2+-ATPase is a protein that can interact with ATPase灏?3 and regulate its activity.

In conclusion, the sodium/potassium-transporting ATPase灏?3 is a critical protein that plays a crucial role in maintaining cellular energy homeostasis. Several studies have identified potential drug targets and biomarkers associated with this protein, including the BH-3 complex and the Ca2+-ATPase . These findings have the potential to lead to new therapeutic strategies for treating various neurological and cardiovascular disorders.

Protein Name: ATPase Na+/K+ Transporting Subunit Beta 3

Functions: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known

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