ATP6V1C1: A Potential Drug Target and Biomarker for Vacuolar Proton Pump C Subunit

Target Name: ATP6V1C1

NCBI ID: G528

ATP6V1C1: A Potential Drug Target and Biomarker for Vacuolar Proton Pump C Subunit

Abstract:

ATP6V1C1 (Vacuolar proton pump C subunit) is a protein that plays a crucial role in the function of vacuolar proton pumps, which are essential for the maintenance of cell homeostasis. The C subunit of the vacuolar proton pump is a target for several drugs, and recent studies have identified its potential as a drug indicator for various diseases. In this article, we will discuss the structure and function of ATP6V1C1, its potential as a drug target, and its potential as a biomarker for various diseases.

Introduction:

ATP6V1C1 (Vacuolar proton pump C subunit) is a protein that is expressed in most eukaryotic cells and is responsible for the maintenance of the proton balance in the vacuolar system. The vacuolar system is a complex organelle that is responsible for the uptake and excretion of nutrients , including protons, and the regulation of the pH of the cytosol. The vacuolar proton pump is a protein complex that is responsible for the delivery of protons from the cytosol to the vacuole.

The C subunit of the vacuolar proton pump is a key protein that is involved in the proton delivery process. The C subunit has four transmembrane domains and is composed of a catalytic center, an ATP-binding site, and a carboxy terminal. is the site of the protein's catalytic activity, and is responsible for the transfer of protons from the cytosol to the vacuole.

Potential as a drug target:

The C subunit of the vacuolar proton pump is a potential drug target due to its involvement in the delivery of protons from the cytosol to the vacuole. Several drugs, including probenecid, have been shown to inhibit the activity of the C subunit and prevent the delivery of protons from the cytosol to the vacuole. These drugs have been shown to be effective in treating various diseases, including heart failure, neurodegenerative diseases, and cancer.

In addition to its potential as a drug target, the C subunit of the vacuolar proton pump is also a potential biomarker for various diseases. The delivery of protons from the cytosol to the vacuole is a critical process that is involved in the regulation of various cellular processes, including cell signaling, pH regulation, and ion transport. Therefore, changes in the delivery of protons to the vacuole can be an indicator of certain diseases, such as heart failure, cancer, and neurodegenerative diseases.

Potential as a biomarker:

The C subunit of the vacuolar proton pump is also a potential biomarker for various diseases due to its involvement in the regulation of cellular processes. The delivery of protons from the cytosol to the vacuole is involved in the regulation of various physiological processes, including the regulation of ion transport, pH regulation, and cell signaling. Therefore, changes in the delivery of protons to the vacuole can be an indicator of certain diseases.

For example, changes in the delivery of protons to the vacuole have been shown to be an indicator of heart failure. Heart failure is a condition in which the heart is unable to pump enough blood to meet the body's needs. The delivery of protons from the cytosol to the vacuole is involved in the regulation of the volume of the ventricular heart muscle, and changes in the delivery of protons to the vacuole have

Protein Name: ATPase H+ Transporting V1 Subunit C1

Functions: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity)

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