AUH: Potential Drug Target Or Biomarker (G549)

Target Name: AUH

NCBI ID: G549

AUH: Potential Drug Target Or Biomarker

AUH (AU RNA binding methylglutaconyl-CoA hydratase, transcript variant 1) is a protein that is expressed in various tissues and cells in the body. It is a key enzyme in the methylation pathway, which is involved in the regulation of gene expression and has been implicated in various diseases, including cancer.

AUH is composed of 21 different amino acids and has a calculated molecular weight of 33.4 kDa. It is localized to the endoplasmic reticulum (ER) and is involved in the metabolism of methylglutaconyl-CoA, a compound that is derived from the amino acids Asp and Glu. Methylglutaconyl-CoA is a precursor to many essential molecules, including fatty acids, steroids, and other compounds that are important for cellular signaling and maintenance.

AUH is regulated by various enzymes and factors, including DNA methylation, histone methylation, and RNA binding proteins. It has been shown to play a role in the regulation of gene expression and has been implicated in the development and progression of various diseases, including cancer.

One of the most promising aspects of AUH is its potential as a drug target or biomarker. The methylation pathway is a promising target for cancer therapy because it has been shown to be involved in the regulation of tumor growth and the development of cancer. By inhibiting the activity of AUH, it may be possible to reduce the levels of methylglutaconyl-CoA and disrupt the methylation pathway, leading to the inhibition of tumor growth and the development of cancer.

Another potential application of AUH is its role in the regulation of cellular signaling. AUH has been shown to play a role in the regulation of various signaling pathways, including the TGF-β pathway, the Wnt pathway, and the Hedgehog pathway. These signaling pathways are involved in the regulation of cellular processes that are important for growth, development, and survival, and may be involved in the development and progression of various diseases. By targeting AUH, it may be possible to develop new treatments for a variety of diseases.

In conclusion, AUH is a protein that is involved in the methylation pathway and has been implicated in the development and progression of various diseases. Its potential as a drug target or biomarker makes it an attractive target for research into the regulation of cellular signaling and the development of new treatments for a variety of diseases. Further research is needed to fully understand the role of AUH in the regulation of cellular processes and to develop new treatments based on its properties.

Protein Name: AU RNA Binding Methylglutaconyl-CoA Hydratase

Functions: Catalyzes the fifth step in the leucine degradation pathway, the reversible hydration of 3-methylglutaconyl-CoA (3-MG-CoA) to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) (PubMed:12434311, PubMed:16640564, PubMed:11738050, PubMed:12655555). Can catalyze the reverse reaction but at a much lower rate in vitro (PubMed:16640564). HMG-CoA is then quickly degraded by another enzyme (such as HMG-CoA lyase) to give acetyl-CoA and acetoacetate (PubMed:16640564). Uses other substrates such as (2E)-glutaconyl-CoA efficiently in vitro, and to a lesser extent 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA), crotonyl-CoA ((2E)-butenoyl-CoA) and 3-hydroxybutanoyl-CoA (the missing carboxylate reduces affinity to the active site) (PubMed:16640564). Originally it was identified as an RNA-binding protein as it binds to AU-rich elements (AREs) in vitro (PubMed:7892223). AREs direct rapid RNA degradation and mRNA deadenylation (PubMed:7892223). Might have itaconyl-CoA hydratase activity, converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, an antimicrobial metabolite and immunomodulator produced by macrophages during certain infections, that can act as a vitamin B12-poisoning metabolite (PubMed:29056341)

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