AZIN1: A Potential Drug Target and Biomarker (G51582)

Target Name: AZIN1

NCBI ID: G51582

AZIN1: A Potential Drug Target and Biomarker

AZIN1 (Aryl hydrocarbon aureoendonuclease 1) is a protein that is expressed in various tissues throughout the body, including the liver, pancreas, and muscle. It is a key enzyme in the metabolic pathway of aryl hydrocarbons, which are the building blocks of many compounds, including drugs, pesticides, and environmental pollutants.

Recent studies have identified AZIN1 as a potential drug target and biomarker for various diseases, including cancer, diabetes, and neurological disorders. This is because of its unique structure and the involvement of multiple cellular pathways, which makes it difficult to target with small molecules.

The inhibition of AZIN1 has been shown to have a variety of therapeutic effects, including the inhibition of cancer cell growth, the regulation of insulin sensitivity, and the protection against neurodegenerative diseases.

One of the main reasons for the potential of AZIN1 as a drug target is its location in the body. As it is expressed in multiple tissues, it is a potential target for drugs that can affect multiple organs and systems. This is especially important for diseases that have a high impact on human health, such as cancer and neurological disorders.

Another reason for its potential as a drug target is its role in the regulation of cellular processes. AZIN1 is involved in the metabolism of aryl hydrocarbons, which are the building blocks of many compounds, including drugs, pesticides, and environmental pollutants. The inhibition of AZIN1 has been shown to have a variety of therapeutic effects, including the inhibition of cancer cell growth and the regulation of insulin sensitivity.

In addition, the unique structure of AZIN1 makes it difficult to target with small molecules. This is because it has a large number of potential binding sites, making it difficult to identify and target specific residues. However, recent studies have identified several potential binding sites on AZIN1 that could be targeted by small molecules.

Furthermore, AZIN1 is also involved in several cellular pathways, including the metabolic, endoplasmic reticulum, and autophagy pathways. This makes it a complex target for drugs that can affect multiple cellular processes.

In conclusion, AZIN1 is a protein that has been identified as a potential drug target and biomarker for various diseases. Its unique structure and involvement in multiple cellular pathways make it difficult to target with small molecules, but recent studies have identified several potential binding sites that could be targeted by small molecules. Further research is needed to determine its full potential as a drug target and biomarker.

Protein Name: Antizyme Inhibitor 1

Functions: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240)

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