BACE2 Regulates Anxiety and Depression in The Brain (G25825)

Target Name: BACE2

NCBI ID: G25825

BACE2 Regulates Anxiety and Depression in The Brain

BACE2 (BACE2 variant b) is a protein that is expressed in the brain and is known for its role in the regulation of anxiety and depression. The BACE2 gene has four splice variants, each of which produces a unique isoform of the protein. One of these variants, BACE2 variant b, is a highly expressed isoform that is involved in the regulation of anxiety and depression.

The BACE2 gene is located on chromosome 12 and encodes a protein that is composed of 211 amino acid residues. The protein has a molecular weight of 24.1 kDa and a pre-protein N-terminus of 20 amino acids. BACE2 is expressed in the brain and is highly expressed in the hippocampus, which is a region of the brain that is responsible for the regulation of emotion and behavior.

BACE2 is involved in the regulation of anxiety and depression by modulating the activity of genes that are involved in mood regulation. Specifically, BACE2 has been shown to regulate the activity of genes that are involved in the production of neurotransmitters, such as dopamine and serotonin. BACE2 has been shown to inhibit the activity of genes that are involved in the production of stress hormones, such as cortisol and adrenaline.

In addition to its role in modulating the activity of genes involved in mood regulation, BACE2 is also involved in the regulation of inflammation in the brain. Specifically, BACE2 has been shown to regulate the activity of immune cells that are involved in inflammation. has been shown to inhibit the activity of immune cells that are involved in the production of pro-inflammatory cytokines, which can contribute to the development of neuroinflammation.

BACE2 is also involved in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time. Specifically, BACE2 has been shown to regulate the activity of genes involved in the formation of synapses, which are the structural elements that allow neural signals to be transmitted from one neural cell to another.

The BACE2 gene has four splice variants, each of which produces a unique isoform of the protein. BACE2 variant b is the most highly expressed isoform and is involved in the regulation of anxiety and depression. BACE2 variant a is the least highly expressed isoform and is involved in the regulation of synaptic plasticity. BACE2 variant c is a splicing intermediate and is involved in the regulation of inflammation. BACE2 variant d is a rare isoform that is not involved in any known function.

Despite its involvement in the regulation of anxiety and depression, BACE2 is not a drug target or biomarker. There are many potential drug targets that are involved in the regulation of anxiety and depression, but BACE2 is not one of them. BACE2 is a protein that is expressed in the brain and is involved in the regulation of important cellular processes that are involved in the development and maintenance of a healthy brain. Further research is needed to determine the role of BACE2 in the regulation of anxiety and depression.

Protein Name: Beta-secretase 2

Functions: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 (PubMed:10591213, PubMed:11083922, PubMed:11423558, PubMed:15857888, PubMed:16816112). Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets (PubMed:23754390). Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142)

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