BBS1: A Protein Regulating NF-Kappa-B and Cellular Stress Response

Target Name: BBS1

NCBI ID: G582

BBS1: A Protein Regulating NF-Kappa-B and Cellular Stress Response

BBS1 (MGC126184) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidney. It is a member of the BBS gene family, which encodes a family of transmembrane proteins that play a role in cell-cell signaling.

One of the functions of BBS1 is to regulate the activity of the protein known as NF-kappa-B, which is a transcription factor that plays a role in various cellular processes, including inflammation, stress response, and cell survival. NF-kappa-B is activated by various factors, including bacterial toxins and cellular stress.

In recent years, researchers have been interested in studying BBS1 as a potential drug target because of its role in NF-kappa-B signaling. Studies have shown that BBS1 can inhibit the activity of NF-kappa-B, which could make it a useful target for drugs that are designed to treat inflammation, stress response, or other conditions that are influenced by NF-kappa-B signaling.

In addition to its role in NF-kappa-B signaling, BBS1 has also been shown to play a role in the regulation of cellular processes that are important for brain function. For example, studies have shown that BBS1 is expressed in the brain and that it is involved in the development and maintenance of neural circuits.

Furthermore, BBS1 has also been shown to be involved in the regulation of cellular processes that are important for tissue repair and regeneration. For example, studies have shown that BBS1 is expressed in various tissues after injury or disease, and that it plays a role in the regulation of the healing process.

Overall, BBS1 is a protein that has been shown to play a role in a wide range of cellular processes, includingNF-kappa-B signaling, cellular stress response, brain function, and tissue repair and regeneration. As a result, it is a potential drug target that could be targeted by small molecules or other therapeutic agents.

Protein Name: Bardet-Biedl Syndrome 1

Functions: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986). Plays a role in olfactory cilium biogenesis/maintenance and trafficking (By similarity)

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