BCL9 Regulates Cell Apoptosis and Survival (G607)

Target Name: BCL9

NCBI ID: G607

BCL9 Regulates Cell Apoptosis and Survival

BCL9 (Bcl-9) is a protein that is expressed in a variety of tissues throughout the body, including the brain, lungs, heart, and gastrointestinal tract. It is a member of the Bcl family of proteins, which are known for their ability to regulate cell death and survival. BCL9 has been shown to play a role in the regulation of cell apoptosis, which is the process by which cells naturally die and are removed from the body.

One of the key functions of BCL9 is its ability to induce apoptosis in cancer cells. Studies have shown that BCL9 can promote the apoptosis of cancer cells by activating programmed cell death (PCD), which is a natural response of cells to harmful stimuli. Activating PCD in cancer cells can be a powerful tool for targeting and destroying these cells, and is a potential mechanism for cancer treatment.

In addition to its role in promoting apoptosis, BCL9 has also been shown to play a role in the regulation of cell survival. By inhibiting the activity of cell-survival signaling pathways, BCL9 has been shown to promote cell death and prevent cell survival. This can be a useful mechanism for targeting diseases where cell survival is fueling the progression of the disease.

Another function of BCL9 is its ability to regulate the formation of blood vessels. Blood vessels are critical for delivering oxygen and nutrients to the body's tissues, but their formation is also a source of damage and disease. BCL9 has been shown to play a role in regulating the formation of blood vessels by inhibiting the activity of angiogenesis-promoting factors. This can be a powerful tool for targeting diseases that are caused by abnormal blood vessel formation.

In conclusion, BCL9 is a protein that has been shown to play a number of important roles in the regulation of cell apoptosis, survival, and formation. Its potential as a drug target or biomarker makes it an attractive target for further research into the mechanisms of disease and the development of new treatments.

Protein Name: BCL9 Transcription Coactivator

Functions: Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity)

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