BCAP31: A Drug Target / Disease Biomarker (G10134)

Target Name: BCAP31

NCBI ID: G10134

BCAP31: A Drug Target / Disease Biomarker

BCAP31 is a protein that is expressed in the brain and is known for its role in the regulation of pain signaling. It is a potential drug target for the treatment of chronic pain conditions such as fibromyalgia, multiple sclerosis, and neurogenic pain.

Research has shown that BCAP31 plays a crucial role in the modulation of pain signaling by neurotransmitters such as serotonin and opioids. It is involved in the regulation of the release of these neurotransmitters and is shown to play a negative role in the modulation of pain.

One of the key features of BCAP31 is its ability to interact with several different neurotransmitters, including serotonin, dopamine, and GABA. These interactions are important for the regulation of pain signaling and are the focus of ongoing research as potential drug targets.

In addition to its role in pain signaling, BCAP31 is also shown to play a role in the regulation of mood and anxiety. It is involved in the regulation of the release of neurotransmitters such as serotonin and cortisol, which are involved in the modulation of mood and anxiety.

The potential drug targets for BCAP31 are numerous and range from neurotransmitter modulation to inflammation and cellular signaling. One of the most promising targets is the use of small molecules that can modulate the activity of BCAP31.

For example, a class of drugs called selective serotonin reuptake inhibitors (SSRIs) have been shown to modulate the activity of BCAP31 in a positive manner. These drugs are commonly used to treat depression and anxiety and have been shown to improve the activity of BCAP31.

Another potential drug target for BCAP31 is the modulation of inflammation. Chronic pain conditions are often associated with inflammation in the brain, and modulation of BCAP31 activity in this regard may be a promising approach to the treatment of chronic pain.

In conclusion, BCAP31 is a protein that is involved in the regulation of pain signaling and has been shown to play a negative role in the modulation of pain. Its potential as a drug target makes it an attractive target for the treatment of chronic pain conditions. Further research is needed to fully understand the role of BCAP31 in pain signaling and to develop effective therapies that target this protein.

Protein Name: B Cell Receptor Associated Protein 31

Functions: Functions as a chaperone protein (PubMed:9396746, PubMed:18287538). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:9396746, PubMed:18287538). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:9396746, PubMed:18287538). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671)

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