BAZ1B: A Protein Regulator of Cell Proliferation and Survival

Target Name: BAZ1B

NCBI ID: G9031

BAZ1B: A Protein Regulator of Cell Proliferation and Survival

BAZ1B (Tyrosine-protein kinase BAZ1B) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key regulator of cell proliferation and survival, and has been implicated in a number of diseases , including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of BAZ1B is its role as a tyrosine-protein kinase, which is a type of enzyme that adds a tyrosine molecule to other proteins. This process is important for the signaling of many different proteins, and is involved in the development and progression of many diseases.

BAZ1B has been shown to be involved in a number of different signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. It has been shown to play a role in the regulation of cell proliferation, differentiation, and survival, and has been implicated in the development of a number of different diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the potential drug targets for BAZ1B is the inhibition of its activity, as this has been shown to have a number of potential therapeutic benefits. In addition, the regulation of BAZ1B activity has also been implicated in the development of certain diseases, and may be a useful biomarker for the diagnosis and treatment of these diseases.

The regulation of BAZ1B activity is involved in a number of different mechanisms, including the inhibition of its catalytic activity by various compounds, such as inhibitors of tyrosine-protein kinase (TK) enzymes, as well as the regulation of its stability and localization in the cell.

In addition to its role in cell signaling, BAZ1B is also involved in the regulation of a number of different cellular processes, including cell adhesion, migration, and the regulation of ion channels. It has also been shown to play a role in the regulation of gene expression, and has been implicated in the development of a number of different diseases.

Overall, BAZ1B is a protein that has important roles in various cellular processes, and is involved in the regulation of cell proliferation, differentiation, and survival. The inhibition of its activity has been shown to have a number of potential therapeutic benefits, and its regulation is an important area of 鈥嬧?媟esearch with implications for the diagnosis and treatment of a number of different diseases.

Protein Name: Bromodomain Adjacent To Zinc Finger Domain 1B

Functions: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136)

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