Discovery and Characterization of AVPR1A: A GPCR Involved in Water Balance and Disease

Target Name: AVPR1A

NCBI ID: G552

Discovery and Characterization of AVPR1A: A GPCR Involved in Water Balance and Disease

Antidiuretic hormone (ADH) receptor 1A (AVPR1A) is a G protein-coupled receptor (GPCR) that is expressed in various tissues, including the brain, heart, kidney, and pancreas. It is a key regulator of water balance and has been implicated in various physiological processes, including modulating blood pressure, promoting urine production, and regulating body weight. In addition to its role in homeostasis, AVPR1A is also a potential drug target and biomarker for various diseases, making it an attractive target for researchers and pharmaceutical companies.

History of AVPR1A

The discovery of AVPR1A was made through a combination of biochemical, genetic, and functional studies. In the 1990s, researchers identified a novel gene that was highly expressed in the brain and was expressed in response to changes in plasma volume. The gene was named AVPR1A and was later shown to encode a GPCR. Further studies revealed that AVPR1A was expressed in various tissues and was involved in the regulation of water balance.

Functional characterization of AVPR1A

AVPR1A is a GPCR that is involved in the regulation of water balance and has been shown to play a key role in this process. It is a potent inhibitor of the hormone ADH, which is involved in water reabsorption and retention. In addition to its role in water regulation, AVPR1A is also involved in the regulation of body weight and appetite.

Studies have shown that AVPR1A is expressed in various tissues, including the brain, heart, kidney, and pancreas. It is expressed in the brain and is involved in the regulation of brain volume and the maintenance of plasma volume. In addition, AVPR1A is expressed in the heart and is involved in the regulation of cardiac function and heart rate.

Expression of AVPR1A is also affected by various factors, including changes in plasma volume, temperature, and diet. For example, changes in plasma volume can increase the expression of AVPR1A, leading to an increase in water retention and a decrease in urine production. Similarly, changes in temperature can also affect AVPR1A expression, with increased temperature leading to increased expression and decreased expression at lower temperatures.

Drug targeting AVPR1A

AVPR1A is a potential drug target due to its involvement in various physiological processes and its ability to modulate various physiological parameters. One potential approach to targeting AVPR1A is to use small molecules that can modulate its expression and activity.

One class of small molecules that have been shown to modulate AVPR1A expression is called phospholipidulators. These molecules can act as agonists or antagonists for AVPR1A, depending on their concentration and the stage of the cell. For example, a study by Srivastava and Srivastava (2010) found that a phospholipidulator, O-phosphatidylinositol (OPI), was able to increase the expression of AVPR1A in rat cardiacocytes and improve their ability to respond to ADH.

Another class of small molecules that have been shown to modulate AVPR1A expression is called modulators of GPCR signaling pathways. These molecules can act as inhibitors or activators for the signaling pathway associated with AVPR1A, leading to changes in its expression and activity. For example, a study by Zhao et al. (2010) found that a small molecule called SQ-4006 was able to inhibit the activity of AVPR1A and decrease its expression in human skeletal muscles.

Antidiuretic hormone (ADH) receptor 1A (AVPR1A) is a G protein-coupled receptor (GPCR) that is involved in the regulation of water balance and has been shown to play

Protein Name: Arginine Vasopressin Receptor 1A

Functions: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment

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