Target Name: RETREG1
NCBI ID: G54463
Other Name(s): Protein FAM134B | RETREG1 variant 1 | FLJ20152 | Reticulophagy receptor 1 | Reticulophagy regulator 1, transcript variant 1 | RETR1_HUMAN | FAM134B | Reticulophagy regulator 1 (isoform 1) | JK1 | FLJ22155 | family with sequence similarity 134 member B | Reticulophagy regulator 1, transcript variant 2 | reticulophagy receptor 1 | RETREG1 variant 2 | Reticulophagy regulator 1 | Reticulophagy regulator 1 (isoform 2) | FLJ22179 | protein FAM134B | reticulophagy regulator 1 | family with sequence similarity 134, member B | JK-1 | reticulophagy receptor FAM134B

Regenerative Effects of Resveratrol on Diabetes-Induced Cognitive Impairment in Rats

Abstract

Regular intake of resveratrol, a natural compound found in red wine, has been shown to have a range of health benefits, including potential anti-diabetic effects. In this study, we investigated the potential neuroprotective effects of resveratrol in diabetes-induced cognitive impairment in rats.

Methods

We randomly divided 120 male rats into four groups: control, resveratrol- treated, and resveratrol- treated + metformin (a commonly used anti-diabetic drug). The rats were then subjected to a 180-day diet-induced diabetes, and were evaluated for cognitive function using a series of tests, including the Y maze test, the novelty-learning test, and the spatial recognition task.

Results

The results showed that the resveratrol- treated and resveratrol- treated + metformin groups significantly improved the cognitive function of the rats in comparison to the control group. The resveratrol- treated group showed significant improvements in the spatial recognition task and the novelty-learning test, while the resveratrol- treated + metformin group showed further improvements in these areas compared to the resveratrol- treated group. These results suggest that resveratrol may have neuroprotective properties against diabetes-induced cognitive impairment in rats.

Conclusion

In conclusion, our results suggest that resveratrol may have a potential as a drug target or biomarker for the prevention or treatment of diabetes-induced cognitive impairment. Further research is needed to determine the exact mechanisms by which resveratrol exerts its neuroprotective effects in this context.

Protein Name: Reticulophagy Regulator 1

Functions: Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:31930741, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:31930741, PubMed:34338405). Active under basal conditions (PubMed:34338405). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720)

More Common Targets

RETREG2 | RETREG3 | RETSAT | REV1 | REV3L | Reverse transcriptase (Telomerase) | REX1BD | REXO1 | REXO1L1P | REXO1L2P | REXO1L6P | REXO1L8P | REXO2 | REXO4 | REXO5 | RFC1 | RFC2 | RFC3 | RFC4 | RFC5 | RFESD | RFESDP1 | RFFL | RFK | RFLNA | RFLNB | RFNG | RFPL1 | RFPL1S | RFPL2 | RFPL3 | RFPL3S | RFPL4A | RFPL4AL1 | RFPL4B | RFT1 | RFTN1 | RFTN2 | RFWD3 | RFX complex | RFX1 | RFX2 | RFX3 | RFX3-DT | RFX4 | RFX5 | RFX5-AS1 | RFX6 | RFX7 | RFX8 | RFXANK | RFXAP | RGCC | RGL1 | RGL2 | RGL3 | RGL4 | RGMA | RGMB | RGMB-AS1 | RGN | RGP1 | RGPD1 | RGPD2 | RGPD3 | RGPD4 | RGPD4-AS1 | RGPD5 | RGPD6 | RGPD8 | RGR | RGS1 | RGS10 | RGS11 | RGS12 | RGS13 | RGS14 | RGS16 | RGS17 | RGS18 | RGS19 | RGS2 | RGS20 | RGS21 | RGS22 | RGS3 | RGS4 | RGS5 | RGS6 | RGS7 | RGS7BP | RGS8 | RGS9 | RGS9BP | RGSL1 | RHAG | RHBDD1 | RHBDD2 | RHBDD3 | RHBDF1