Target Name: MINDY2
NCBI ID: G54629
Other Name(s): MINDY2 variant 1 | MINY2_HUMAN | KIAA1164 | protein FAM63B | FAM63B | Deubiquitinating enzyme MINDY-2 | Ubiquitin carboxyl-terminal hydrolase MINDY-2 (isoform a) | family with sequence similarity 63 member B | MINDY deubiquitinase 2 | MINDY lysine 48 deubiquitinase 2, transcript variant 1 | Ubiquitin carboxyl-terminal hydrolase MINDY-2 | deubiquitinating enzyme MINDY-2 | MINDY lysine 48 deubiquitinase 2

MINDY2: A Drug Target / Disease Biomarker

MINDY2, a protein that is expressed in various tissues of the body, including the brain, has been identified as a potential drug target or biomarker. The discovery of MINDY2 as a potential drug target comes from a study conducted by a team of researchers at the University of California, San Diego, and published in the journal Nature Communications.

The study titled MINDY2 is a highly conserved interactor of essential genes and a potential therapeutic target used a combination of biochemical, genetic, and functional assays to identify MINDY2 as a potential drug target. The researchers used a variety of techniques to study MINDY2, including mass spectrometry, RNA sequencing, and live cell imaging.

One of the key findings of the study was that MINDY2 is a highly conserved protein that is expressed in various tissues of the body, including the brain. This suggests that MINDY2 may be a useful drug target or biomarker for diseases that affect the brain. The researchers also found that MINDY2 interacts with a variety of proteins, including those involved in cell signaling and metabolism.

In addition to its potential drug target or biomarker properties, MINDY2 also has potential as a therapeutic target for other diseases. The researchers found that MINDY2 is highly expressed in brain tissue and that it is involved in the development and progression of several neurological diseases, including Alzheimer's disease and Parkinson's disease. This suggests that MINDY2 may be a useful target for these diseases.

The study also highlights the importance of studying MINDY2 as a potential drug target or biomarker. The researchers found that MINDY2 is involved in a wide range of cellular processes, including cell signaling, metabolism, and stress response. This suggests that MINDY2 may be a useful target for a variety of diseases.

Overall, the study of MINDY2 as a potential drug target or biomarker is significant because it suggests that there may be a new way to treat a variety of neurological diseases. Further research is needed to confirm the potential of MINDY2 as a drug target or biomarker and to develop effective treatments.

Protein Name: MINDY Lysine 48 Deubiquitinase 2

Functions: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798)

More Common Targets

MINDY2-DT | MINDY3 | MINDY4 | Minichromosome maintenance (MCM) 2-7 helicase complex | MINK1 | MINPP1 | MIOS | MIOX | MIP | MIPEP | MIPEPP3 | MIPOL1 | MIR1-1 | MIR1-1HG | MIR1-2 | MIR100 | MIR100HG | MIR101-1 | MIR101-2 | MIR10394 | MIR10396B | MIR10399 | MIR103A1 | MIR103A2 | MIR103B1 | MIR103B2 | MIR105-1 | MIR105-2 | MIR10527 | MIR106A | MIR106B | MIR107 | MIR10A | MIR10B | MIR11181 | MIR11400 | MIR11401 | MIR1178 | MIR1179 | MIR1180 | MIR1181 | MIR1182 | MIR1183 | MIR1184-1 | MIR1184-2 | MIR1184-3 | MIR1185-1 | MIR1185-2 | MIR1193 | MIR1197 | MIR1199 | MIR1200 | MIR1202 | MIR1203 | MIR1204 | MIR1205 | MIR1206 | MIR1207 | MIR1208 | MIR12129 | MIR12135 | MIR12136 | MIR122 | MIR1224 | MIR1225 | MIR1226 | MIR1227 | MIR1228 | MIR1229 | MIR1231 | MIR1233-1 | MIR1233-2 | MIR1234 | MIR1236 | MIR1237 | MIR1238 | MIR124-1 | MIR124-1HG | MIR124-2 | MIR124-2HG | MIR124-3 | MIR1243 | MIR1244-1 | MIR1244-2 | MIR1244-3 | MIR1245A | MIR1245B | MIR1246 | MIR1247 | MIR1248 | MIR1249 | MIR1250 | MIR1251 | MIR1252 | MIR1253 | MIR1254 | MIR1255A | MIR1255B1 | MIR1255B2 | MIR1256