MFN1: A Protein in Cell-cell and Cell-extracellular Matrix Interactions, Integration, Inflammation

Target Name: MFN1

NCBI ID: G55669

MFN1: A Protein in Cell-cell and Cell-extracellular Matrix Interactions, Integration, Inflammation

MFN1 (FLJ20693) is a protein that is expressed in various tissues of the body, including the brain, heart, and blood vessels. It is a member of the Integrin alpha-2 (Ia2) family, which is a group of transmembrane proteins that are involved in cell-cell and cell-extracellular matrix interactions.

One of the unique features of MFN1 is its ability to interact with integrins, which are a type of protein that is found on the surface of many cells. Integrins are involved in many different processes in the body, including cell adhesion, migration, and invasion. MFN1 plays a key role in these processes by helping to regulate the interactions between cells and the extracellular matrix.

MFN1 has also been shown to be involved in the regulation of inflammation and immune response. It has been shown to play a key role in the recruitment of immune cells to sites of infection or inflammation, and it has been shown to contribute to the regulation of the inflammatory response.

In addition to its role in cell-cell and cell-extracellular matrix interactions, MFN1 has also been shown to have other important functions in the body. For example, it has been shown to play a key role in the regulation of cell proliferation, and it has been shown to contribute to the development and maintenance of cancer.

MFN1 has also been shown to be involved in the regulation of the blood-brain barrier, which is a specialized barrier that helps to protect the brain from harmful substances that are circulating in the blood. This is important because the blood-brain barrier is not as selective as the barrier that separates the brain from the body, and it is possible for harmful substances to enter the brain and cause damage. MFN1 plays a key role in regulating the blood-brain barrier by helping to keep it tight and restrictive.

In conclusion, MFN1 (FLJ20693) is a protein that is involved in a wide range of important functions in the body. Its ability to interact with integrins, regulate cell proliferation and inflammation, and regulate the blood-brain barrier makes it an attractive drug target and a potential biomarker for a variety of diseases. Further research is needed to fully understand the role of MFN1 in the body and to develop effective treatments for the conditions that it is involved in.

Protein Name: Mitofusin 1

Functions: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303)

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