MGAT3: A Potential Drug Target for Neurological Disorders (G4248)

Target Name: MGAT3

NCBI ID: G4248

Other Name(s): Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, transcript variant 1 | Beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase | N-acetylglucosaminyltransferase III | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase | Uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III | GlcNAc-T III | mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase | MGAT3_HUMAN | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III | MGAT3 variant X1 | GNT3 | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (isoform X1) | Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, transcript variant X1 | MGAT3 variant 1 | GNT-III

MGAT3: A Potential Drug Target for Neurological Disorders

MGAT3 (Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase) is a gene that encodes a protein involved in the glucosaminyl transfer process in the nervous system. The glucosaminyl transfer process is the final step in the synthesis of the neurotransmitter acetylcholine, which is responsible for the transmission of signals in the nervous system. MGAT3 has been shown to play a role in the regulation of this process, and is therefore a potential drug target or biomarker.

MGAT3 is a member of the glycoprotein family, which includes a variety of proteins that are involved in the transport of various biomolecules in the body. MGAT3 is specifically involved in the transport of glucosaminyl, a type of sugar that is found in many neurotransmitters, including those that regulate mood, pain, and other neurological processes.

MGAT3 is expressed in many different tissues throughout the body, including the brain, spinal cord, and peripheral nerves. It is primarily located in the axon, which is the long, thread-like structure that carries nerve signals from the brain to the rest of the body. MGAT3 is shown to be highly expressed in the axon, and is also found in the dendrites, which are the branching extensions of neurons that receive signals from the axon.

MGAT3 has been shown to play a role in the regulation of the glucosaminyl transfer process in the nervous system. It is expressed in the axon and the dendrites of neurons and is involved in the transfer of glucosaminyl to the presynaptic terminal. MGAT3 has been shown to regulate the amount of glucosaminyl that is transferred to the axon, and is thought to play a role in the development of neurotransmitter dysfunction in the brain.

In addition to its role in the regulation of the glucosaminyl transfer process, MGAT3 is also shown to play a role in the regulation of the acetylcholine synthesis and storage process. The acetylcholine is a neurotransmitter that is involved in the transmission of signals in the nervous system, and is synthesized from the amino acid choline. MGAT3 is shown to be involved in the synthesis and storage of acetylcholine, and is thought to play a role in the regulation of its levels in the brain.

MGAT3 is also shown to play a role in the regulation of the neurotransmitter synthesis and storage process in the brain. It is expressed in the axon and the dendrites of neurons, and is involved in the synthesis and storage of neurotransmitters such as dopamine, serotonin, and GABA. MGAT3 is thought to play a role in the regulation of the levels of these neurotransmitters in the brain, and is therefore thought to be involved in the development of neurotransmitter dysfunction in the brain.

In conclusion, MGAT3 is a protein that is involved in the regulation of the glucosaminyl transfer process in the nervous system. It is expressed in many different tissues throughout the body, including the brain, spinal cord, and peripheral nerves, and is primarily located in the axon. MGAT3 is thought to play a role in the regulation of the acetylcholine synthesis and storage process, and is also shown to be involved in the regulation of the neurotransmitter synthesis and storage process in the brain. As a result, MGAT3 is a potential drug target or biomarker for a variety of neurological disorders.

Protein Name: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Functions: It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate (PubMed:19403558). Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location (PubMed:19403558). Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation (PubMed:26801611). In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage (By similarity)

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