PSMB2: A Promising Drug Target and Biomarker for Proteasome-Mediated Cellular Signaling

Target Name: PSMB2

NCBI ID: G5690

PSMB2: A Promising Drug Target and Biomarker for Proteasome-Mediated Cellular Signaling

Proteasomes are complex protein structures that play a central role in regulating various cellular processes. They are involved in the degradation of damaged or unnecessary proteins, as well as the delivery of proteins for protein synthesis and other cellular events. The proteasome system is composed of several subunits, including the alpha, beta, and gamma subunits, which are involved in the recognition and cleavage of protein substrates. One of the key protein substrates for the proteasome is the heat shock protein (HSP) which are involved in the adaptation of cells to high temperatures and other stress conditions.

PSMB2, also known as Proteasome subunit beta type-2 (isoform 2), is one of the key subunits of the proteasome system. It is a 28 kDa protein that plays a critical role in the recognition and cleavage of HSPs. HSPs are highly conserved proteins that are involved in various cellular processes, including stress response, DNA damage repair, and cell survival. They are also implicated in various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases.

PSMB2 functions as a protein kinase-associated protein (PKAP) and is involved in the regulation of cellular processes such as cell growth, apoptosis, and autophagy. It is a key regulator of the proteasome-mediated degradation of HSPs and is involved in the delivery of HSPs to the cytoplasm for protein degradation.

PSMB2 is a potential drug target and biomarker for various diseases. Its functions in the regulation of cellular processes make it an attractive target for small molecule inhibitors, which can be used to treat diseases associated with the over-expression or dysfunction of PSPB2.

PSMB2-Driven Cellular Signaling

PSMB2 is involved in several cellular signaling pathways, including the regulation of cell growth, apoptosis, and autophagy. It is a key regulator of the proteasome-mediated degradation of HSPs, which are involved in the regulation of various cellular processes, including stress response, DNA damage repair, and cell survival.

PSMB2 plays a critical role in the regulation of cell growth by controlling the entry of new resources into the cell. It does this by regulating the activity of several cell signaling pathways, including the TOR signaling pathway. The TOR signaling pathway is involved in the regulation of cell growth, cell division, and metabolism, and is a key regulator of cell survival.

PSMB2 is also involved in the regulation of apoptosis, which is the natural programmed cell death that occurs in various organisms. It is a key regulator of the apoptosis-associated protein (AP-1) which is involved in the regulation of cell death.

PSMB2 is also involved in the regulation of autophagy, which is the process of the self-cleaning of the cells. It is a key regulator of the autophagy-associated protein (AP-3) which is involved in the regulation of cell cleaning.

PSMB2-Driven therapeutic Strategies

The over-expression or dysfunction of PSPB2 has been implicated in the development of various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. To treat these diseases, there is a need for strategies that can inhibit the over-expression or dysfunction of PSPB2.

One approach to treating PSPB2-related diseases is the use of small molecule inhibitors. These inhibitors can be used to inhibit the activity of PSPB2, which can

Protein Name: Proteasome 20S Subunit Beta 2

Functions: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

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