TOMM22: A Protein Involved in Intracellular Signaling and Tissue Growth Development

Target Name: TOMM22

NCBI ID: G56993

TOMM22: A Protein Involved in Intracellular Signaling and Tissue Growth Development

TOMM22 (MST065) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the TOMM family of proteins, which are known for their role in intracellular signaling. TOMM22 is highly conserved across various species, and its sequence is similar to that of TOMM20, a protein that has been shown to play a role in the regulation of mitochondrial function and metabolism.

The TOMM22 protein is composed of 22 amino acid residues and has a calculated molecular mass of 33.9 kDa. It is expressed in a variety of tissues, including the brain, heart, and kidneys, and is also found in the placenta and testes. TOMM22 is highly conserved, with only four amino acid residues being found to be highly conserved across different species.

One of the key functions of TOMM22 is its role in intracellular signaling. TOMM22 has been shown to play a role in the regulation of mitochondrial function and metabolism, and is involved in the negative regulation of the activity of the enzyme Pyruvate Carrier. This enzyme is responsible for transporting pyruvate across the mitochondrial membrane and is a key regulator of cellular energy metabolism.

In addition to its role in intracellular signaling, TOMM22 is also involved in the regulation of cellular processes that are important for tissue growth and development. For example, TOMM22 has been shown to play a role in the regulation of cell proliferation, and is involved in the negative regulation of the activity of the enzyme cyclin D1. This enzyme is responsible for regulating the cycle of cell division, and TOMM22 is shown to play a role in the regulation of its activity.

TOMM22 is also involved in the regulation of cellular processes that are important for inflammation and immune response. For example, TOMM22 has been shown to play a role in the regulation of the production of pro-inflammatory cytokines, such as TNF-alpha and IL-18. This suggests that TOMM22 may be involved in the regulation of an immune response that is important for the regulation of inflammation.

In conclusion, TOMM22 is a protein that is expressed in various tissues of the body and is involved in a variety of cellular processes that are important for tissue growth, development, and immune response. Its role in intracellular signaling and the regulation of mitochondrial function and metabolism suggests that TOMM22 may be a drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of TOMM22 in cellular processes and its potential as a therapeutic target.

Protein Name: Translocase Of Outer Mitochondrial Membrane 22

Functions: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (PubMed:10982837). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity)

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