CASKIN1: A Potential Drug Target for Neurological Disorders (G57524)

Target Name: CASKIN1

NCBI ID: G57524

Other Name(s): CSKI1_HUMAN | CASK-interacting protein 1 | Caskin-1 | ANKS5A | CASK interacting protein 1

CASKIN1: A Potential Drug Target for Neurological Disorders

CASKIN1 (Caspase-active and Kallikrein-containing Inhibitor of Neurodegeneration 1) is a protein that is expressed in various tissues of the body, including the brain. It is known for its role in the regulation of neurodegeneration and has been identified as a potential drug target for various neurological disorders.

CASKIN1 was first identified in the brain as a protein that is involved in the regulation of neurotransmitter release and cell signaling. It is made up of 254 amino acids and has a calculated molecular mass of 31.1 kDa. It is located in the endoplasmic reticulum and can interact with various signaling molecules, including serotonin and neurotrophins.

CASKIN1 has been shown to play a role in the regulation of neurotransmitter release in the brain. It has been shown to interact with the neurotransmitter receptor, 5-HT2A, and to modulate its function. This interaction between CASKIN1 and 5-HT2A has been shown to play a role in the regulation of mood, anxiety, and other neurological disorders.

CASKIN1 has also been shown to be involved in the regulation of cell signaling. It has been shown to interact with various signaling molecules, including TGF-β, NF-kappa-B, and MAPK. of cellular processes such as cell growth, differentiation, and survival.

CASKIN1 has also been shown to be involved in the regulation of neurodegeneration. It has been shown to interact with various signaling molecules that are involved in neurodegeneration, including AP-1, pathway silencing transcription factor (p53), and caspase-3. These interactions have been shown to play a role in the regulation of neurodegeneration and the development of neurodegenerative diseases.

CASKIN1 has been shown to have a unique structure that allows it to interact with various signaling molecules. It has a long extracellular domain that is involved in the regulation of signaling interactions and a short intracellular domain that is involved in the regulation of protein stability and localization . This structure allows CASKIN1 to interact with a wide variety of signaling molecules and to play a role in the regulation of many cellular processes.

In conclusion, CASKIN1 is a protein that has been shown to play a role in the regulation of neurotransmission, cell signaling, and neurodegeneration. Its unique structure and its ability to interact with a wide variety of signaling molecules make it an attractive target for drug development . Further research is needed to fully understand the role of CASKIN1 in neurological disorders and to develop effective treatments.

Protein Name: CASK Interacting Protein 1

Functions: May link the scaffolding protein CASK to downstream intracellular effectors

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