Regulating DNA Replication: The Role of RPLP2 (G6181)

Target Name: RPLP2

NCBI ID: G6181

Regulating DNA Replication: The Role of RPLP2

The protein RPLP2 (D11S2243E) is a key regulator of the Replication Protein Complex (RPC), a protein complex involved in DNA replication in eukaryotic cells. RPLP2 is a 21-kDa protein that consists of 195 amino acid residues and has been shown to play a critical role in regulating DNA replication in various cell types.

The RPLP2 gene

The RPLP2 gene is located on chromosome 11q22 and has a size of 13.9 kb. The gene encodes a protein that consists of 195 amino acid residues, with the last 24 amino acids being the tail of the protein. RPLP2 is a member of the P11 subfamily of the Rho family of proteins, which are involved in regulating various cellular processes, including cytoskeletal organization, cell adhesion, and signaling pathways.

Expression and function

RPLP2 is expressed in various cell types, including human T cells, and its expression is regulated by various intracellular signaling pathways, including TGF-β, NF-kappa-B, and PI3K-Akt signaling pathways. For example, RPLP2 has been shown to be regulated by the TGF-β pathway, which is involved in cell growth, differentiation, and survival.

In addition to its role in regulating DNA replication, RPLP2 is also involved in various signaling pathways. For example, it has been shown to be involved in the regulation of cell adhesion, as well as in the regulation of cytoskeletal organization and cell signaling pathways.

Drug targeting

Due to its involvement in various signaling pathways, RPLP2 has been identified as a potential drug target. Several studies have shown that inhibiting RPLP2 can lead to the inhibition of various cellular processes, including cell growth, differentiation, and survival.

One of the most promising compounds that has been shown to target RPLP2 is the drug curacilin, which is a small molecule inhibitor of RPLP2. Curacilin has been shown to inhibit the activity of RPLP2 and to reduce the amount of DNA replicated in various cell types.

Another study has shown that the drug PD01323, which is a small molecule inhibitor of the protein kinase B, can also inhibit the activity of RPLP2 and to reduce the amount of DNA replicated in various cell types.

Conclusion

In conclusion, RPLP2 is a key regulator of the Replication Protein Complex and has been shown to play a critical role in regulating various cellular processes. Its expression is regulated by various intracellular signaling pathways, including TGF-β, NF-kappa-B, and PI3K- Akt signaling pathways, and it is also involved in various signaling pathways. The drug curacilin and PD01323 have been shown to be effective in inhibiting the activity of RPLP2 and to reduce the amount of DNA replicated in various cell types. Further studies are needed to understand the full function and potential of RPLP2 as a drug target.

Protein Name: Ribosomal Protein Lateral Stalk Subunit P2

Functions: Plays an important role in the elongation step of protein synthesis

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