ACOT6: Key Enzyme in Fatty Acid Metabolism (G641372)

Target Name: ACOT6

NCBI ID: G641372

ACOT6: Key Enzyme in Fatty Acid Metabolism

Acyl-CoA thioesterase 6 (ACOT6) is a protein that is expressed in various tissues throughout the body, including the liver, heart, and kidneys. It is a key enzyme in the acyl-CoA (acyl-CoA) thioesterase pathway, which is a central metabolic pathway that is involved in the production and storage of fatty acids. The ACOT6 gene has four splice variants, and one of them is a transcribed protein that is widely expressed in various tissues.

The ACOT6 gene is located on chromosome 16 at position 6. It is a member of the superfamily of CoA thioesterases, which are a group of enzymes that are involved in the production and storage of fatty acids. The ACOT6 protein is a 21-kDa protein that consists of 125 amino acid residues. It has a molecular weight of 23,712 and a calculated pI of 6.9.

The ACOT6 gene is expressed in various tissues throughout the body, including the liver, heart, and kidneys. It is highly expressed in the liver, where it is responsible for the production of a variety of fatty acids, including fatty acids that are involved in energy metabolism. The ACOT6 gene is also expressed in the heart and kidneys, where it is involved in the production of fatty acids that are involved in cell signaling and inflammation.

The ACOT6 protein is involved in a number of different cellular processes. It is a key enzyme in the acyl-CoA thioesterase pathway, which is a central metabolic pathway that is involved in the production and storage of fatty acids. the production of fatty acids from acyl-CoA, which is a key step in the synthesis of fatty acids.

The ACOT6 protein is also involved in the storage of fatty acids. It is a key enzyme in the fatty acid transport system, which is responsible for transporting fatty acids from the cytosol to the mitochondria. The ACOT6 protein helps to regulate the transport of fatty acids into the mitochondria, where they can be used for energy metabolism.

The ACOT6 gene has four splice variants, and one of them is a transcribed protein that is widely expressed in various tissues. The most abundant splice variant is exon 1, which is responsible for the production of the full-length ACOT6 protein. The exon 1 protein is involved in the production of fatty acids from acyl-CoA, as well as the storage of fatty acids in the cytosol.

In addition to its role in fatty acid metabolism, the ACOT6 protein is also involved in a number of other cellular processes. It is a key enzyme in the production of fatty acids from aryl hydrocarbon precursors, which are molecules that can be used to synthesize fatty acids. The ACOT6 protein is also involved in the production of fatty acids from ketones, which are molecules that can be used as a source of energy in the body.

The ACOT6 protein is also involved in the regulation of cellular processes that are related to inflammation. It is a key enzyme in the production of fatty acids from aryl hydrocarbon precursors, which can be used to generate pro-inflammatory molecules. involved in the production of fatty acids from ketones, which can be used as a source of energy in the body and can contribute to inflammation.

The ACOT6 gene is a promising drug target for a number of different diseases. For example, it is

Protein Name: Acyl-CoA Thioesterase 6

Functions: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Catalyzes the hydrolysis of phytanoyl-CoA and pristanoyl-CoA, two methyl-branched fatty acids derived from phytol, that enter the body via the diet

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