A Potential Drug Target or Biomarker: Unveiling the Role of LOC645181 (PDGFA Associated Protein 1 Pseudogene)
A Potential Drug Target or Biomarker: Unveiling the Role of LOC645181 (PDGFA Associated Protein 1 Pseudogene)
Introduction
Location 645181 (LOC645181) is a pseudogene that is highly expressed in various tissues, including brain, heart, and muscle. Its gene has been well- conserved across various species, which suggests that it may play a critical role in the development and maintenance of these tissues. However, its function and clinical relevance remain poorly understood.
Recent studies have identified LOC645181 as a promising drug target or biomarker, which may be involved in various physiological processes, including cell growth, metabolism, and inflammation. This article will delve into the molecular and clinical aspects of LOC645181, highlighting its potential as a drug target and biomarker.
Molecular Characterization
LOC645181 is a 21-kDa protein that is highly expressed in the brain, heart, and muscle. It is localized to the nuclear envelope and has been observed in various cellular organelles, including the endoplasmic reticulum, endosomal system, and mitochondria. LOC645181 has been shown to interact with various protein partners, including PDGF-A, NF-kappa-B, and TGF-β.
Expression and Function
Several studies have demonstrated that LOC645181 is involved in various cellular processes, including cell growth, apoptosis, and inflammation. For instance, LOC645181 has been shown to promote the growth of cancer cells and contribute to their survival. Additionally, LOC645181 has been linked to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases.
In addition to its role in disease, LOC645181 has also been identified as a potential drug target. Its highly conserved sequence and multiple bioactive interactions suggest that it may become an ideal drug target. Currently, researchers are exploring the development of new drugs to treat a variety of diseases by targeting the specific mechanism of LOC645181.
Clinical Relevance
The identification of LOC645181 as a potential drug target or biomarker has significant implications for the development of new therapies. By targeting LOC645181, researchers may be able to improve treatment outcomes for various diseases, including neurodegenerative diseases, cancer, and cardiovascular diseases.
In conclusion, LOC645181 is a pseudogene that has been well- conserved across various species and has been implicated in various cellular processes. Its potential as a drug target or biomarker has been identified, and further studies are needed to fully understand its role in disease and its potential as a therapeutic approach.
Protein Name: PDGFA Associated Protein 1 Pseudogene
More Common Targets
LOC645188 | LOC645266 | LOC645468 | LOC645503 | LOC645967 | LOC646044 | LOC646214 | LOC646358 | LOC646471 | LOC646674 | LOC646736 | LOC646762 | LOC646813 | LOC646836 | LOC646853 | LOC646903 | LOC646934 | LOC646970 | LOC647115 | LOC647132 | LOC647481 | LOC649133 | LOC650157 | LOC650226 | LOC651536 | LOC652276 | LOC652608 | LOC653303 | LOC653503 | LOC653513 | LOC653631 | LOC653653 | LOC653698 | LOC727751 | LOC728024 | LOC728098 | LOC728114 | LOC728138 | LOC728376 | LOC728392 | LOC728417 | LOC728485 | LOC728554 | LOC728660 | LOC728688 | LOC728715 | LOC728739 | LOC728743 | LOC728877 | LOC728989 | LOC729086 | LOC729164 | LOC729173 | LOC729218 | LOC729296 | LOC729444 | LOC729609 | LOC729683 | LOC729732 | LOC729737 | LOC729815 | LOC729870 | LOC729887 | LOC729966 | LOC729973 | LOC730098 | LOC730100 | LOC730101 | LOC730183 | LOC730234 | LOC730338 | LOC730668 | LOC90246 | LOC91450 | LOC93429 | LOC93463 | LOC93622 | LOH12CR2 | Long intergenic non-protein coding RNA 1336 | Long intergenic non-protein coding RNA 205 | Long intergenic non-protein coding RNA 266-4, pseudogene | Long-chain-fatty-acid--CoA ligase | LONP1 | LONP2 | LONRF1 | LONRF2 | LONRF3 | LORICRIN | LOX | LOXHD1 | LOXL1 | LOXL1-AS1 | LOXL2 | LOXL3 | LOXL4 | LPA | LPAL2 | LPAR1 | LPAR2 | LPAR3
