UBA1: Mice's Toxin-Detecting Enzyme (G7317)

Target Name: UBA1

NCBI ID: G7317

UBA1: Mice's Toxin-Detecting Enzyme

UBA1 (A1S9T), also known as UBA1 mouse protein, is a protein that is expressed in the brain and other tissues of mice. It is a member of the UBA1 gene family, which encodes a protein that is involved in the detoxification of xenobiotics, such as drugs and other harmful substances.

The UBA1 gene was identified in the mouse gene database using a bioinformatics analysis, and it is located on chromosome 6 at position 182.3. The UBA1 gene is transcribed into a protein that is 1,943 amino acids long and has a calculated molecular weight of 21.4 kDa.

UBA1 is expressed in a variety of tissues and organs in the mouse body, including the brain, heart, and kidneys. It is highly expressed in the brain, with higher levels of expression observed in the prefrontal cortex and other areas of the brain involved in higher cognitive function.

In addition to its expression in the brain, UBA1 is also expressed in other tissues and organs, including the liver, pancreas, and red blood cells. It is also highly expressed in the placenta, which supports the development and maintenance of fetal tissue.

The UBA1 protein is involved in the detoxification of xenobiotics, which are substances that can harmful to the body. Xenobiotics can include drugs, as well as other substances that are not naturally occurring in the body but are introduced into the body through diet or other means.

UBA1 is involved in the detoxification of xenobiotics through the UBA1 enzyme, which is a member of the superfamily of cysteine 鈥嬧?媝roteases. The UBA1 enzyme is responsible for the detoxification of a wide variety of xenobiotics, including drugs, as well as other Substances that are not naturally occurring in the body but are introduced into the body through diet or other means.

UBA1 is also involved in the detoxification of xenobiotics through the UBA1-dependent pathway, which is a multi-component pathway that involves the expression of several genes involved in the detoxification of xenobiotics. This pathway is expressed in many different tissues and organs in the body , including the brain, heart, and kidneys.

In addition to its involvement in the detoxification of xenobiotics, UBA1 is also involved in several other cellular processes in the body. It is a component of the endoplasmic reticulum (ER), which is the system responsible for the transport and storage of cellular organelles. It is also involved in the regulation of mitochondrial function, as well as in the development and maintenance of the nervous system.

UBA1 is also involved in several different diseases and conditions, including drug addiction, alcoholism, and aging. It is also a potential drug target, as several studies have identified UBA1 as a potential target for small molecules and other compounds that can modulate its activity.

In conclusion, UBA1 (A1S9T) is a protein that is expressed in the brain and other tissues of mice. It is a member of the UBA1 gene family and is involved in the detoxification of xenobiotics, as well as several other cellular processes in the body . It is also involved in several diseases and conditions, including drug addiction, alcoholism, and aging. As a potential drug target, UBA1 is a focus of ongoing research in the field of pharmacology and toxicology.

Protein Name: Ubiquitin Like Modifier Activating Enzyme 1

Functions: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334)

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