Unlocking The Potential of UBE4A: A Protein Target for Cancer and Other Diseases

Target Name: UBE4A

NCBI ID: G9354

Unlocking The Potential of UBE4A: A Protein Target for Cancer and Other Diseases

UBE4A (UBOX2) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and gastrointestinal tract. It is a member of the UBOX gene family, which is known for its role in regulating gene expression and intracellular signaling pathways. UBE4A has been shown to play a role in several cellular processes, including cell adhesion, migration, and angiogenesis.

One of the most promising aspects of UBE4A is its potential as a drug target. UBE4A has been shown to interact with several protein molecules, including the transcription factor NF-kappa-B and the protein kinase PDGFR-尾. These interactions suggest that UBE4A may be a useful target for drugs that are designed to modulate these signaling pathways.

In addition to its potential as a drug target, UBE4A is also a potential biomarker for several diseases. For example, UBE4A has been shown to be downregulated in several types of cancer, including breast, lung, and colorectal cancer. This suggests that UBE4A may be a useful biomarker for these diseases, and that targeting UBE4A in combination with other therapies may be a promising strategy for cancer treatment.

Another potential application of UBE4A is its role in cell adhesion and migration. UBE4A has been shown to play a role in the formation of tight junctions, which are specialized barriers that maintain the integrity of epithelial cells. These barriers are critical for maintaining tissue structure and function, and are often disrupted in diseases such as cancer.

UBE4A may also be a useful target for diseases that involve inflammation and fibrosis. For example, UBE4A has been shown to be involved in the regulation of the immune response and has been implicated in the development of autoimmune diseases. Additionally, UBE4A has been shown to play a role in the regulation of fibrosis, a condition in which tissues become abnormally thickened and can cause a range of diseases, including heart failure and cancer.

In conclusion, UBE4A is a protein that has been shown to play a role in several cellular processes, including cell adhesion, migration, and angiogenesis. Its potential as a drug target and biomarker make it an attractive target for further research and development. Further studies are needed to fully understand the role of UBE4A in these processes and to determine its potential as a therapeutic agent.

Protein Name: Ubiquitination Factor E4A

Functions: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates

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